Interstrand Interactions between Side Chains in a Double-Helical Foldamer

摘要

Not so long ago the propensity of a polymeric or oligomeric molecular strand to fold into a well-defined conformation in solution was believed to be mainly a property of biopolymers such as proteins and nucleic acids.Recent studies on foldamers-artificial oligomers that also adopt well-defined folded conformations-have led to a fundamental paradigm shift,and biopolymers are now considered to be one of many classes of molecules that fold.Up to now,studies on foldamers have focused on the prime sources of folding,which are main-chain (backbone) conformational preferences and main-chain/main-chain interactions.