Topochemical Polymerization in Supramolecular Polymers of Oligopeptide-Functionalized Diacetylenes

摘要

New generations of synthetic polymers targeting applications at the interface of optoelectronics and the biosciences must speak the language of biomaterials and mimic their functioning. They must provide the chemical functionality to interact with biological systems on the molecular level and exhibit a similar ability to form hierarchical structures.[1] Supramolecular self-assembly has proven to be a powerful tool for the preparation of materials with structural features on the nanometer scale.[2] Recently, the self-assembly of oligopeptides through aggregation and formation of sheets has received increasing attention. This approach has been prompted by research activities in the field of neurodegenerative diseases.[3] Notable examples include the self-assembly of oligopeptides based on amyloids,[4] the formation of organogels from synthetic oligopeptides and their deposition on surfaces,[5] the aggregation of peptidomimetic molecules[6] and PEG conjugates,[7] multiblock copolymers inspired by spider silk,[8] as well as the use of self-assembled oligopeptides in the manufacture of gold nanowires.