Enantioselective Total Synthesis of 3-Hydroxy-7-kemp-8(9)-en-6-one, a Diterpene Isolated from Higher Termites

摘要

The first total synthesis of the title diterpene was accomplished starting from the Wieland-Miescher ketone. A diastereoselective sulfa-Michael addition enabled the generation of the delicate ,-unsaturated ketone moiety, while the tetracyclic kempane skeleton was readily constructed through domino metathesis.