Enantioselective Direct Mannich-Type Reactions Catalyzed by Frustrated Lewis Acid/BrOnsted Base Complexes

摘要

An enantioselective direct Mannich-type reaction catalyzed by a sterically frustrated Lewis acid/BrOnsted base complex is disclosed. Cooperative functioning of the chiral Lewis acid and achiral BrOnsted base components gives rise to insitu enolate generation from monocarbonyl compounds. Subsequent reaction with hydrogen-bond-activated aldimines delivers -aminocarbonyl compounds with high enantiomeric purity.