Deprotonative metalation,whereby a proton is substituted by a metal cation to transform a parent organic compound to a more reactive metallic intermediate,which,in turn,can be used to transfer the organic fragment to another molecule,is one of the fundamental synthetic tools that chemists employ to construct compounds.111 Thus this indispensable tool is put to labor on a daily basis in laboratories across the world,both in academia,for general synthesis,and in industry,for the manufacture of fine chemicals and Pharmaceuticals.With polyatomic organic compounds containing two or more hydrogen atoms,there is often a requirement to be selectivein choosing the specific hydrogen atom to be removed to generate the desired organic fragment.Owing largely to their polar nature,alkali-metal alkyl ("RM") and amide ("R2NM") compounds,especially those of lithium,are often the best reagents for effecting deprotonative metalation,but there are limits to their selectivity.
展开▼
机译：脱质子化金属化，质子被金属阳离子取代，从而将母体有机化合物转化为更具反应性的金属中间体，而该中间体又可以用于将有机片段转移至另一个分子，是基本的合成工具之一111因此，这个必不可少的工具每天都在世界各地的实验室中投入使用，无论是在学术界，一般合成还是工业领域，都可以用于制造精细化学品和制药。使用多原子有机化合物包含两个或多个氢原子，通常需要选择性地选择要去除的特定氢原子以生成所需的有机片段。碱金属烷基（“ RM”）和酰胺（“ R 2 NM”）化合物，特别是锂的化合物，通常是实现去质子化金属的最佳试剂，但是其选择性受到限制。
展开▼
