Molecular Recognition by Glycoside Pseudo Base Pairs and Triples in an Apramycin-RNA Complex

摘要

The ribosome and its RNA components are targets for a diverse set of antibiotics,including the natural aminoglyco-sides,macrolides,and tetracyclins and the synthetic oxazoli-dinones,all of which interfere with bacterial protein synthesis.Crystallographic analyses of ribosomal subunits and domains thereof in complex with antibiotics have demonstrated that the natural products interact almost exclusively with ribosomal RNA components(rRNA),a result that lends support to earlier biochemical findings and underlines the importance of RNA as a drug target.