Nitroarenes as the Nitrogen Source in Intermolecular Palladium-Catalyzed Aryl C-H Bond Aminocarbonylation Reactions

摘要

A three-component palladium-catalyzed aminocarbonylation of aryl and heteroaryl sp(2) C-H bonds using nitroarenes as the nitrogen source was achieved using Mo-(CO)(6) as the reductant and origin of the CO. This intermolecular C-H bond functionalization does not requires any exogenous ligand to be added, and our mechanism experiments indicate that the palladacycle catalyst serves two roles in the aminocarbonylation reaction: reduce the nitroarene to a nitrosoarene and activate the sp(2) C-H bond.