An N,N'-Dioxide/In(OTf)3 Catalyst for the Asymmetric Hetero-Diels-Alder Reaction Between Danishefsky's Dienes and Aldehydes:Application in the Total Synthesis of Triketide

摘要

Highly substituted dihydropyranones are key structural elements in many bioactive natural products and important pharmaceuticals,and asymmetric hetero-Diels-Alder (HDA) reactions between Danishefsky's dienes and carbonyl compounds have been shown to be the most powerful and straightforward approach to these optically active dihydropyranones.