Cholesterol seco-Sterol-Induced Aggregation of Methylated Amyloid-beta Peptides-Insights into Aldehyde-Initiated Fibrillization of Amyloid-beta

摘要

The nucleation and aggregation of amyloid-beta (A beta) peptides,A beta(1-40) and A beta(1-42),into neurotoxic oligomers is considered a primary event in Alzheimer's disease (AD) pathogenesis.The vast majority of this disease is sporadic in origin (> 85%),involving the oligomerization of native A beta peptide oligomers,therefore,research is ongoing to classify the in vivo environmental triggers of AD onset that facilitate intracellular and extracellular nucleation,aggregation and deposition of native A beta peptide.