Stereoretentive Halogenations and Azidations with Titanium(IV) Enabled by Chelating Leaving Groups

摘要

Stereospecific functional group conversions of nonraeemic alcohols and diols and their derivatives are of increasing importance given the powerful catalytic asymmetric reactions available for their synthesis. If neighboring-group participa-tion and metal-catalyzed allylic substitution are excluded, there are exceedingly few reports of nucleophilic displacement reactions on unactivated saturated carbon leading to products with a high degree of retention of configuration.