Direct,Highly Enantioselective Pyrrolidine Sulfonamide Catalyzed Michael Addition of Aldehydes to Nitrostyrenes

摘要

The Michael addition reaction is without question one of the most general and versatile methods for formation of C-C bonds in organic synthesis.Thus,it is not surprising that the development of enantioselective catalytic protocols for this cornerstone reaction has received much attention.Efforts aimed at achieving asymmetric versions of the process by using chiral organocatalysts have been explored intensively in recent years.