Synthesis and Quantitative Evaluation of Glycero-D-manno-heptose Binding to Concanavalin A by Fluorous-Tag Assistance

摘要

Herein we report the first use of a quantitative fluorous microarray strategy to show that the mannose-binding lectin concanavalin A(conA),contrary to prevailing belief,actually can accept modifications of the mannose at the C-6 position in the form of glycero-manno-heptoses found on pathogenic bacteria(Figure 1).