Highly Enantioselective Aza-Baylis-Hillman Reaction in a Chiral Reaction Medium

摘要

A chemical reaction that leads to enantiomerically enriched products can in principle be carried out with a source of chirality in any of the involved components - starting materials,[1] catalysts,[2] or reaction media.[3] To date, all asymmetric transformations that yield appreciable enantioselectivities are based on the first two strategies. Herein we report the first example of a highly enantioselective asymmetric synthesis in which only the reaction medium contains chiral information.