Enantioselective Nazarov Cyclizations Catalyzed by an Axial Chiral C6F5-Substituted Boron Lewis Acid

摘要

A chiral variant of B(C6F5)(3) with a 3,3-disubstituted binaphthyl backbone is shown to catalyze Nazarov cyclizations with high levels of enantio- and diastereocontrol. The parent B(C6F5)(3) also promotes these ring closures efficiently. This electrocyclization is another example of the still small family of C-C bond formations mediated by B(C6F5)(3) as the catalyst.