Iridium-Catalyzed Reductive Alkylations of Secondary Amides

摘要

Reported herein is the first direct, metal-catalyzed reductive functionalization of secondary amides to give functionalized amines and heterocycles. The method is shown to have exceptionally broad scope with respect to suitable nucleophiles, which cover both hard and soft Cnucleophiles as well as a Pnucleophile. The reaction exhibits good chemoselectivity and tolerates several sensitive functional groups.