Chemoenzymatic Deracemization of Chiral Sulfoxides

摘要

The highly enantioselective enzyme methionine sulfoxide reductaseA was combined with an oxaziridine-type oxidant in a biphasic setup for the deracemization of chiral sulfoxides. Remarkably, high eevalues were observed with a wide range of substrates, thus providing a practical route for the synthesis of enantiomerically pure sulfoxides.