Bis(Dpa-ZnII) Appended Xanthone: Excitation Ratiometric Chemosensor for Phosphate Anions

摘要

The development of molecular-recognition and sensing systems for biologically important anions has received considerable attention in recent years.[1] Among various anions, phosphate derivatives, which include nucleoside pyrophosphates such as adenosine triphosphate (ATP),[2] inorganic pyrophosphate,[3] and phosphoproteins,[4] are significant sensing targets because of their pivotal roles in biological systems. For example, ATP is known not only as a universal energy source but also as an extracellular signaling mediator in many biological processes,[5] and protein phosphorylation is recognized as a ubiquitous regulatory mechanism of signal transduction cascades in living cells.[6] In recent years, several chemosensors that exhibit a rather strong binding affinity for the phosphate derivatives in aqueous medium were reported,[2d],[e], [3a],[c], [4] although their bioanalytical application in biological systems has not yet been sufficiently developed.[2e], [3c], [7]