Synthesis of Functionalized Cyclopentenes through Catalytic Asymmetric [3+2] Cycloadditions of Allenes with Enones

摘要

Five-membered carbocycles are a common substructure in a wide array of natural and nonnatural products. Among this family of compounds, cyclopentenes are particularly important targets, in part because derivatization of the olefin often occurs with good diastereoselectivity, thereby providing access to highly functionalized, stereochemically complex cyclopentanes. Although considerable progress has been described in developing methods for the asymmetric synthesis of cyclopentenes, the number of effective catalytic enantioselective processes is comparatively small.