Synthesis of alpha-Fluoroketones by Insertion of HF into a Gold Carbene

摘要

Reported is an efficient synthesis of alpha-fluoroketones by insertion of hydrogen fluoride (HF) into the gold carbene intermediate, generated from a cationic gold catalyzed addition of N-oxides to alkynes. This method results in excellent chemical yields for a wide range of alkyne substrates and demonstrates good functional-group tolerance.