Enantioselective Palladium-Catalyzed Cross-Coupling of alpha-Bromo Carboxamides and Aryl Boronic Acids

摘要

We herein report an enantioselective palladium-catalyzed cross-coupling between alpha-bromo carboxamides and aryl boronic acids, generating a series of chiral alpha-aryl carboxamides in good yields and excellent enantioselectivities. The development of a chiral P,P=O ligand was critical in overcoming the second transmetalation issue and allows the first asymmetric palladium-catalyzed coupling of alpha-bromo carbonyl compounds.