C-C Bond Formation of Benzyl Alcohols and Alkynes Using a Catalytic Amount of (KOBu)-Bu-t: Unusual Regioselectivity through a Radical Mechanism

摘要

We report a C-C bond-forming reaction between benzyl alcohols and alkynes in the presence of a catalytic amount of (KOBu)-Bu-t to form alpha-alkylated ketones in which the C=O group is located on the side derived from the alcohol. The reaction proceeds under thermal conditions (125 degrees C) and produces no waste, making the reaction highly atom efficient, environmentally benign, and sustainable. Based on our mechanistic investigations, we propose that the reaction proceeds through radical pathways.