Conformational Re‐engineering of Porphyrins as Receptors with Switchable N?H???X‐Type Binding Modes

摘要

Abstract > The selectivity and functional variability of porphyrin cofactors are typically based on substrate binding of metalloporphyrins wherein the pyrrole nitrogen units only serve to chelate the metal ions. Yet, using the porphyrin inner core system for other functions is possible through conformational engineering. As a first step towards porphyrin “enzyme‐like” active centers, a structural and spectroscopic study of substrate binding to the inner core porphyrin system shows that a highly saddle‐distorted porphyrin with peripheral amino receptor groups ( 1 , 2,3,7,8,12,13,17,18‐octaethyl‐5,10,15,20‐tetrakis(2‐aminophenyl)porphyrin) coordinates analytes in a switchable manner dependent on the acidity of the solution. The supramolecular ensemble exhibits exceptionally high affinity to and selectivity for the pyrophosphate anion (2.26±0.021)×10 9 ? <sc>m</sc> ?1 . 1 H?NMR spectroscopic studies provided insight into the likely mode of binding and the characterization of atropisomers, all four of which were also studied by X‐ray crystallography. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > 卟啉辅因子的选择性和功能可变性通常基于金属卟啉的底物结合，其中吡咯氮单元仅用于螯合金属离子。然而，通过构象工程，可以使用卟啉内核系统进行其他功能。作为探针卟啉“酶样”活性中心的第一步，对内芯卟啉系统结合的基材的结构和光谱研究表明，具有外周氨基受体基团的高鞍扭曲的卟啉（ 1 </ b> ，2,3,7,8,12,13,17,18-18-八甲基-5,10,15,20-四（2-氨基苯基）卟啉）以可切换方式坐标，取决于溶液的酸度。超分子集合对焦磷酸根阴离子（2.26±0.021）×10表示异常高亲和力和选择性 9 </ sup> 还 <sc> m </ sc> ？1 </ sup> 。 1 </ sup> H = NMR光谱研究提供了对可能的结合模式和阿托异构体的表征的洞察，其中四种也是通过X射线晶体学研究的。 </ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-19011/'>《Angewandte Chemie》</a> <b style="margin: 0 2px;">|</b><span>2019年第46期</span><b style="margin: 0 2px;">|</b><span>共5页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1188.html" title="应用化学">应用化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=conformational design&option=203" rel="nofollow">conformational design;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=nonplanar porphyrins&option=203" rel="nofollow">nonplanar porphyrins;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=porphyrinoids&option=203" rel="nofollow">porphyrinoids;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=pyrophosphate&option=203" rel="nofollow">pyrophosphate;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=sensors&option=203" rel="nofollow">sensors;</a> </p> <div class="translation"> 机译：构象设计;非平面卟啉;卟啉;焦磷酸盐;传感器; 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Peter Littlewood</a> <span> <a href="/conference-cn-61813/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 2017浦江创新论坛 </a> <span> <span> . 2017</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020312653686.html">重新设计血红素活性中心调控肌红蛋白的多重催化功能</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=吴磊彬&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 吴磊彬</a> <span> . 2017</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120473517.html">具有六种速度比的机电变速器以及重新设计变速器的方法</a> <b>[P]</b> . <span> 中国专利： CN100480541C </span> <span> . 2009.04.22</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120105174427.html">具有六种速度比的机电变速器以及重新设计变速器的方法</a> <b>[P]</b> . <span> 中国专利： CN1971090A </span> <span> . 2007-05-30</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130444630384.html">ANTIBODY COMPETITON BINDING ASSAY FOR QUALITATIVE DETECTION OF THE CONFORMATION CHANGES AND CONFORMATION-DEPENDENT QUANTITATIVE DETECTION OF GLYCOPROTEIN P AND OTHER CELL SURFACE RECEPTORS, PUMPS AND PROTEINS, AND USES THEREOF</a> <b>[P]</b> . <span> 外国专利：  HU0100948A2 </span> <span> . 2003-02-28</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：用于糖蛋白P及其他细胞表面受体，泵和蛋白质的构象变化的定性检测和构象依赖性定量检测的抗体竞争结合测定及其用途 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130449058459.html">ANTIBODY COMPETITON BINDING ASSAY FOR QUALITATIVE DETECTION OF THE CONFORMATION CHANGES AND CONFORMATION-DEPENDENT QUANTITATIVE DETECTION OF GLYCOPROTEIN P AND OTHER CELL SURFACE RECEPTORS, PUMPS AND PROTEINS, AND USE THEREOF</a> <b>[P]</b> . <span> 外国专利：  HU0100948D0 </span> <span> . 2001-05-28</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：用于糖蛋白P和其他细胞表面受体，泵和蛋白质的构象变化的定性检测和构象依赖性定量的抗体竞争结合测定及其用途 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130446859679.html">Appropriate methods to typify prpsc and to alter the conformation of prpsc, use of an agent capable of affecting the binding of prpsc to one or more divalent metal ions, methods of screening for an agent capable of altering the conformation of type 1 and / or prpsc type 2 and screening for an agent for use in the diagnostic prevention and / or treatment of prion disease, use of an agent obtainable by a method, kit, type 2 isolated prpsc, and use of type 2 isolated prpsc</a> <b>[P]</b> . <span> 外国专利：  BR0009675A </span> <span> . 2002-03-26</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：表征prpsc和改变prpsc构象的适当方法，使用能够影响prpsc与一种或多种二价金属离子结合的试剂，筛选能够改变1型和/或prpsc构象的试剂的方法类型2和筛选可用于诊断性预防和/或治疗病毒疾病的药物，使用可通过方法，试剂盒获得的药物，2型分离的prpsc和2型分离的prpsc </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704028164173','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img src="https://cdn.zhangqiaokeyan.com/img/loginclose.png" alt="关闭" 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