Universal Scaffold for an Activatable Photosensitizer with Completely Inhibited Photosensitivity

摘要

Abstract > Activatable photosensitizers (aPSs) sensitive to specific stimuli hold potential for targeting multiple disease biomarkers and are desirable for photodynamic therapy (PDT). Presented herein is the design of aPSs that can be activated and fully recover from an inhibited state in the presence of specific biomarker. A designed long‐wavelength D‐π‐A photosensitizer, PS <sub>Se‐I</sub> , with highly efficient photosensitivity for generation of 1 O <sub>2</sub> was used. Caging of the phenolate donor of PS <sub>Se‐I</sub> with a biomarker‐sensitive group provided ALP PS , and the drastic activation of its photosensitivity was demonstrated intracellularly. To enhance the flexibility of the design strategy, a clickable azide group was introduced into the scaffold to allow integration of more functionality. Modularly derived mito‐PN PS , equipped with a mitochondria‐targeting group and a specific peroxynitrite‐reactive trigger, was synthesized and demonstrated superior performance in cells. This strategy could lead to customization of aPSs applicable to a specific PDT. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > 对特异性刺激的可活性光敏剂（APS）对靶向多种疾病生物标志物的潜力敏感，并且对于光动力治疗（PDT）是期望的。本文呈现的是在特定生物标志物存在下可以被激活并完全从抑制状态恢复的APS的设计。设计的长波长D-π-A光敏剂， PS. <sem> se-i </ sub> </ b> ，具有高效的光敏性的产生 1 </ sup> O. <sub> 2 </ sub> 用过。捕获酚类供体的笼子 PS. <sem> se-i </ sub> </ b> 提供生物标志物敏感组 alp </ b> </ sup> ps </ b> 并且，细胞内展示其光敏性激活的激活。为提高设计策略的灵活性，将可点击的叠氮群组引入脚手架中，以允许整合更多功能。模块化衍生 mito-pn </ b> </ sup> ps </ b> 配备有线粒体靶向组和特定的过氧亚硝酸盐反应性触发，在细胞中阐述了优异的性能。该策略可能导致适用于特定PDT的APSS的定制。 </ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-19011/'>《Angewandte Chemie》</a> <b style="margin: 0 2px;">|</b><span>2019年第46期</span><b style="margin: 0 2px;">|</b><span>共9页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1188.html" title="应用化学">应用化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=anticancer&option=203" rel="nofollow">anticancer;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=charge transfer&option=203" rel="nofollow">charge transfer;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=photochemistry&option=203" rel="nofollow">photochemistry;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=photodynamic therapy&option=203" rel="nofollow">photodynamic therapy;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=singlet oxygen&option=203" rel="nofollow">singlet oxygen;</a> </p> <div class="translation"> 机译：抗癌;电荷转移;光化学;光动力疗法;单线氧; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704028164160.html">Universal Scaffold for an Activatable Photosensitizer with Completely Inhibited Photosensitivity</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> </a> <a href="/journal-foreign-19011/" target="_blank" rel="nofollow" class="tuijian_authcolor">Angewandte Chemie .</a> <span>2019</span><span>,第46期</span> </span> </div> <p class="zwjiyix translation" style="max-width: 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</div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020316249552.html">用于光动力疗法的红光吸收的可激活光敏剂的设计与合成</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=吕维杰&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 吕维杰</a> <span> . 2019</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120112319032.html">用于治疗、预防或改善阿尔茨海默氏症的组合物、用于抑制脑神经细胞死亡的组合物、用于抑制由β淀粉样蛋白诱导的小胶质细胞激活的组合物、及用于抑制由β淀粉样蛋白诱导的PGE2、TNF-α或IL-1β产生的组合物</a> <b>[P]</b> . <span> 中国专利： CN112351790A </span> <span> . 2021-02-09</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120101089663.html">用于治疗肥胖及相关病症的肌肉生长抑制素、激活素或激活素受体拮抗剂</a> <b>[P]</b> . <span> 中国专利： CN110087684A </span> <span> . 2019-08-02</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130425381009.html">Method of photosensitizer activation, treatment method with application of activated photosensitizer and photosensitizer application to prepare medicine</a> <b>[P]</b> . <span> 外国专利：  KZ24152B </span> <span> . 2011-06-15</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：光敏剂活化的方法，使用活化光敏剂的治疗方法和光敏剂用于制备药物 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130447665395.html">COMPLEX BORON COMPOUND, PHOTOSENSITIZER PRODUCED BY USING THE COMPOUND, PHOTOSENSITIVE RESIN COMPOSITION PRODUCED BY USING THE PHOTOSENSITIZER AND USE THEREOF</a> <b>[P]</b> . <span> 外国专利：  JP2002265443A </span> <span> . 2002-09-18</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：复合硼化合物，使用该化合物生产的光敏树脂组合物，使用光敏剂生产的光敏树脂组合物及其用途 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130429245290.html">Use of photosensitizer for cleaning air, water or contaminated surfaces and in filters, where the photosensitizer is covalently linked and/or linked over physical interaction to surface and activated by visible light to form singlet oxygen</a> <b>[P]</b> . <span> 外国专利：  DE102008020755A1 </span> <span> . 2009-10-22</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：使用光敏剂清洁空气，水或受污染的表面以及在过滤器中，其中光敏剂通过物理相互作用与表面共价连接和/或连接，并被可见光激活以形成单线态氧 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img 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