Regioselective Arene C?H Alkylation Enabled by Organic Photoredox Catalysis

Holmberg‐Douglas Natalie; Onuska Nicholas P. R.; Nicewicz David A.

摘要

Abstract > Expanding the toolbox of C?H functionalization reactions applicable to the late‐stage modification of complex molecules is of interest in medicinal chemistry, wherein the preparation of structural variants of known pharmacophores is a key strategy for drug development. One manifold for the functionalization of aromatic molecules utilizes diazo compounds and a transition‐metal catalyst to generate a metallocarbene species, which is capable of direct insertion into an aromatic C?H bond. However, these high‐energy intermediates can often require directing groups or a large excess of substrate to achieve efficient and selective reactivity. Herein, we report that arene cation radicals generated by organic photoredox catalysis engage in formal C?H functionalization reactions with diazoacetate derivatives, furnishing sp 2 –sp 3 coupled products with moderate‐to‐good regioselectivity. In contrast to previous methods utilizing metallocarbene intermediates, this transformation does not proceed via a carbene intermediate, nor does it require the presence of a transition‐metal catalyst. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > 扩展适用于复杂分子的后期修饰的C的工具箱是药物化学的感兴趣，其中已知药物的结构变体的制备是药物发育的关键策略。用于芳族分子的官能化的一种歧管利用重氮化合物和过渡金属催化剂产生金属甲苯物质，其能够将其直接插入芳族C-H键。然而，这些高能量中间体通常需要引导基团或大量过量的基材以获得有效和选择性的反应性。在此，我们报告称，通过有机摄影氧化氧催化在正式的C-H官能化反应中产生的芳烃阳离子自由基与二氮酸酯衍生物，提供SP 2 </ sup> -sp. 3 </ sup> 耦合产品，具有中等至良好的区域选择性。与先前的使用金属甲苯中间体的方法相比，该转化不会通过卡宾中间体进行，也不需要存在过渡金属催化剂。 </ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-19011/'>《Angewandte Chemie》</a> <b style="margin: 0 2px;">|</b><span>2020年第19期</span><b style="margin: 0 2px;">|</b><span>共5页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Holmberg‐Douglas Natalie&option=202" target="_blank" rel="nofollow">Holmberg‐Douglas Natalie;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Onuska Nicholas P. R.&option=202" target="_blank" rel="nofollow">Onuska Nicholas P. R.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Nicewicz David A.&option=202" target="_blank" rel="nofollow">Nicewicz David A.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of ChemistryUniversity of North Carolina at Chapel HillChapel Hill NC 27599-3290 USA;</p> <p>Department of ChemistryUniversity of North Carolina at Chapel HillChapel Hill NC 27599-3290 USA;</p> <p>Department of ChemistryUniversity of North Carolina at Chapel HillChapel Hill NC 27599-3290 USA;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1188.html" title="应用化学">应用化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=alkylation&option=203" rel="nofollow">alkylation;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=arenes&option=203" rel="nofollow">arenes;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=diazo compounds&option=203" rel="nofollow">diazo compounds;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=organic photoredox catalysis&option=203" rel="nofollow">organic photoredox catalysis;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=synthetic methods&option=203" rel="nofollow">synthetic methods;</a> </p> <div class="translation"> 机译：烷基化;arenes;重氮化合物;有机摄影氧催化;合成方法; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704028162556.html">Regioselective Arene C?H Alkylation Enabled by Organic Photoredox Catalysis</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Holmberg‐Douglas Natalie&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Holmberg‐Douglas Natalie,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Onuska Nicholas P. R.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Onuska Nicholas P. R.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Nicewicz David A.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Nicewicz David A. </a> <a href="/journal-foreign-19011/" target="_blank" rel="nofollow" class="tuijian_authcolor">Angewandte Chemie .</a> <span>2020</span><span>,第19期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：通过有机光致毒性催化使能芳烃C'H烷基化。</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-foreign_journal-the-american-chemical-society_thesis/0204112819505.html">Enantioselective Allylic Alkylation with 4-Alkyl-1,4-dihydro- pyridines Enabled by Photoredox/Palladium Cocatalysis</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Hong-Hao&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Zhang Hong-Hao,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhao Jia-Jia&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Zhao Jia-Jia,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yu Shouyun&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Yu Shouyun </a> <a href="/journal-foreign-719/" target="_blank" rel="nofollow" class="tuijian_authcolor">Journal of the American Chemical Society .</a> <span>2018</span><span>,第49期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：光氧化还原/钯共催化的4-烷基-1,4-二氢吡啶对映体选择性烯丙基烷基化</span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704020415986.html">Radical Alkylation of Imines with 4-Alkyl-1,4-dihydropyridines Enabled by Photoredox/Bronsted Acid Cocatalysis</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Hong-Hao&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Zhang Hong-Hao,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yu Shouyun&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Yu Shouyun </a> <a href="/journal-foreign-30984/" target="_blank" rel="nofollow" class="tuijian_authcolor">The Journal of Organic Chemistry .</a> <span>2017</span><span>,第19期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：用光致毒剂/刚反导酸性酸可通过4-烷基-1,4-二氢吡啶的亚胺烷基化烷基化</span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-conference-foreign_meeting-289074_thesis/0705016410125.html">Direct Allylic C?H Alkylation of Enol Silyl Ethers Enabled by Photoredox-Bronsted Base Hybrid Catalysis</a> <b>[C]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=NAKASHIMA Tsubasa&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">NAKASHIMA Tsubasa,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=OHMATSU Kohsuke&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">OHMATSU Kohsuke,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=OOI Takashi&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">OOI Takashi </a> <a href="/conference-foreign-289074/" target="_blank" rel="nofollow" class="tuijian_authcolor">日本化学会春季年会講演予稿集 .</a> <span>2018</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：直接烯丙基C-H烷基化烯醇甲硅烷基醚化的光毒氧化物基杂交催化催化</span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-degree-foreign_mphd_thesis/02061866210.html">New Frontiers in Organocatalysis and Photoredox Catalysis: Oxy-Allyl Cations as a Novel Platform of Asymmetric Electrophilic Activation and Photoredox Enabled Site-Selective Bioconjugation</a> <b>[D] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liu, Chun.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Liu, Chun. </a> <span>2017</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：有机成分分析和Photoreox催化剂中的新边界：氧 - 烯丙基阳离子作为非对称亲电子激活和光毒的位点选择性生物杂交的新型平台</span> </p> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-journal-foreign-pmc_detail_thesis/040004600705.html">Direct allylic C–H alkylation of enol silyl ethers enabled by photoredox–Brønsted base hybrid catalysis</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kohsuke Ohmatsu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Kohsuke Ohmatsu,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tsubasa Nakashima&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Tsubasa Nakashima,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Makoto Sato&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Makoto Sato,</a> <span>-1</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：通过光氧化还原-布朗斯台德碱杂化催化实现烯醇甲硅烷基醚的直接烯丙基CH烷基化</span> </p> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/open-access_resources_thesis/01000126248007.html">Regioselective Arene C−H Alkylation Enabled by Organic Photoredox Catalysis</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Natalie Holmberg‐Douglas&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Natalie Holmberg‐Douglas,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Nicholas P. R. Onuska&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Nicholas P. R. Onuska,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=David A. Nicewicz&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">David A. Nicewicz </a> <span>2020</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：有机摄影氧催化使能芳烃C-H烷基化催化</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_asian-journal-ecotoxicology_thesis/0201216832964.html">多环芳烃典型电子性质与其大型蚤光致毒性的构效关系研究</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=谷成刚&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 谷成刚</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=朱梦荣&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,朱梦荣</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘畅&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,刘畅</a> <span> <a href="/journal-cn-9795/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 生态毒理学报 </a> </span> <span> . 2017</span><span>,第003期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_inorganic-chemicals-industry_thesis/0201248644686.html">固体酸催化混合芳烃烷基化制备高沸芳烃</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=周立坤&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 周立坤</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=臧甲忠&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,臧甲忠</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=黄贵洪&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,黄贵洪</a> <span> <a href="/journal-cn-9230/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 无机盐工业 </a> </span> <span> . 2017</span><span>,第007期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_petroleum-refining_thesis/0201230537025.html">流化催化裂化尾气中烯烃通过催化蒸馏与芳烃烷基化</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Part.EE&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Part.EE</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杨诒春&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,杨诒春</a> <span> <a href="/journal-cn-27805/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 石油炼制译丛 </a> </span> <span> . 1989</span><span>,第002期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_coal-conversion_thesis/0201242489874.html">1-十六烯烷基化降低煤沥青中毒性多环芳烃含量的研究</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=周常行&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 周常行</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘刚&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,刘刚</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王玉高&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,王玉高</a> <span> <a href="/journal-cn-13263/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 煤炭转化 </a> </span> <span> . 2018</span><span>,第004期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_qilu-petrochemical-technology_thesis/0201297454157.html">改进的催化烷基化、烷基化催化剂和制备烷基化催化剂的方法</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . </a> <span> <a href="/journal-cn-7871/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 齐鲁石油化工 </a> </span> <span> . 2018</span><span>,第2期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-20087_thesis/0202227460.html">芳烃歧化与烷基化反应工业催化剂应用</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=赵红霞&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 赵红霞</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王承学&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,王承学</a> <span> <a href="/conference-cn-20087/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 第4届全国工业催化技术及应用年会 </a> <span> <span> . 2007</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020313328157.html">蒽醌类和多环芳烃类化合物对水生生物的急性光致毒性及QSAR研究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王莹&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 王莹</a> <span> . 2009</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120104429163.html">用含有改进的β－沸石的催化剂使芳烃烷基化</a> <b>[P]</b> . <span> 中国专利： CN1227770A </span> <span> . 1999-09-08</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120112732320.html">脱除有机溶剂中碱性含氮物质的方法和芳烃烷基化反应的方法及芳烃烷基化反应的装置</a> <b>[P]</b> . <span> 中国专利： CN112755591A </span> <span> . 2021-05-07</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130401465026.html">Photoredox-Catalyzed Direct C-H Functionalization of Arenes</a> <b>[P]</b> . <span> 外国专利：  US2020002284A1 </span> <span> . 2020-01-02</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：光氧化还原催化的芳烃直接C-H功能化 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130404558514.html">Photoredox-catalyzed direct Camp;#x2014;H functionalization of arenes</a> <b>[P]</b> . <span> 外国专利：  US10399947B2 </span> <span> . 2019-09-03</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：光氧化还原催化的芳烃直接C＆＃x2014; H功能化 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130407271765.html">PHOTOREDOX-CATALYZED DIRECT C-H FUNCTIONALIZATION OF ARENES</a> <b>[P]</b> . <span> 外国专利：  US2018148414A1 </span> <span> . 2018-05-31</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：光催化氧化芳烃的直接C-H功能 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704028162556','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img src="https://cdn.zhangqiaokeyan.com/img/loginclose.png" alt="关闭" onclick="$('.journalsub-pop-up').hide()"> <p class="pardon">抱歉，该期刊暂不可订阅，敬请期待！</p> <p class="current">目前支持订阅全部北京大学中文核心（2020）期刊目录。</p> <div style="display: flex;margin-top: 69px;justify-content: space-between;"> <div class="no-sub" onclick="$('.journalsub-pop-up').hide()">暂不订阅</div> <div class="other-sub" onclick="continueSub('from=pc-detail')">继续订阅其他期刊</div> </div> </div> </div> <div class="right_btn"> <ul> <li class="gouwuche">  </li> <li class="yijian"> <a href="javascript:void(0);" onclick="link_analysis('/mycenter/auth/complaint.html',this)" title="意见反馈">意见反馈</a> </li> <li class="top"> <a href="javascript:scrollTo(0,0);" title="回到顶部">回到顶部</a> </li> <li class="shouye"> <a href="/" title="首页">回到首页</a> </li> </ul> </div> <div class="xllindexfooter"> <div class="xllindexfootercenter"> <div class="xllindexfooterleft left" > <div class="xllindexfooterleftli"> <ul> <li><a href="/about.html" title="关于掌桥">关于掌桥</a></li> <li><a href="/help/helpmap.html" title="资源导航">资源导航</a></li> <li><a href="/help/helpguide.html" title="新手指南">新手指南</a></li> <li><a href="/help/helpcenter.html" title="常见问题">常见问题</a></li> <li><a href="/sitemap.html" title="网站地图">网站地图</a></li> <li><a href="/help/helpcenter.html?type=9" title="版权声明">版权声明</a></li> </ul> </div> <div class="xllindexfooterleft"> <p class="xllindexfooterlefteamil">客服邮箱：kefu@zhangqiaokeyan.com</p> <div class="xllindexfooterlefttcp"> <div class="xllindexfooterpoliceiimg"></div> <div class="xllindexfooterpoliceispan"> <span>京公网安备：11010802029741号 </span> <span>ICP备案号：<a href="https://beian.miit.gov.cn" rel="nofollow" target="_blank" title="ICP备案号">京ICP备15016152号-6</a></span> <span>六维联合信息科技 (北京) 有限公司©版权所有</span> </div> </div> </div> </div> <div class="xllindexfooterright left"> <ul> <li> <p style="font-weight: bold;">客服微信</p> <div></div> </li> <li> <p style="font-weight: bold;">服务号</p> <div></div> </li> </ul> </div> </div> </div> <span id="0704028162556down" data-source="7," data-out-id="7+ysKSKFXRpaKWhzmBJ/+6MYo12LS6jhWoHCQqozVfGM28SWBiw+4nkXnX750RnT," data-f-source-id="7" data-title="Regioselective Arene C?H Alkylation Enabled by Organic Photoredox Catalysis" data-price="20" data-site-name="" data-transnum="24" style="display:none;"></span> <input type="hidden" value="4" id="sourcetype"> <input type="hidden" value="19011" id="journalid"> <input type="hidden" value="1" id="inyn_provide_service_level"> <input type="hidden" value="https://cdn.zhangqiaokeyan.com" id="imgcdn"> <input type="hidden" value="1" id="isdeatail"> <input type="hidden" value="" id="syyn_indexed_database"> <input type="hidden" value="" id="servicetype"> <input type="hidden" id="pagename" value="Regioselective Arene C?H Alkylation Enabled by Organic Photoredox Catalysis"/> <input type="hidden" value="thesis_get_original" id="pageIdentification"> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery-1.12.4.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/lwlh_ajax.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zq.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/common.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery.cookie.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/top.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/tip.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/login.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/down.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/search.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/newmail.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/searchtype.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/user/regist.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zxs_solor/detail.js?v=5.7.8"></script> <script type="text/javascript" src="https://www.zhangqiaokeyan.com/statistics/static/pagecollection.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/tj.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/sse.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/pushbaidu.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/history.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/util/cookie.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/weipu/weipu.js?v=5.7.8"></script> </body> <script> $(function(){ var weiPuStatus = getCookie('WeiPuStatus'); if(weiPuStatus){ tipWeiPuStatus(weiPuStatus); delCookie('WeiPuStatus'); } getFacetKeywordVoInId(); var sourcetype = $("#sourcetype").val(); var inyn_provide_service_level = $("#inyn_provide_service_level").val(); if((sourcetype ==1||sourcetype==4)&&inyn_provide_service_level!=4){ getJournal(); } }) </script> </html>