Tumor Microenvironment‐Activated NIR‐II Nanotheranostic System for Precise Diagnosis and Treatment of Peritoneal Metastasis

Ling Sisi; Yang Xiaohu; Li Chunyan; Zhang Yejun; Yang Hongchao; Chen Guangcun; Wang Qiangbin

摘要

Abstract > Activatable theranostic systems show potential for improved tumor diagnosis and therapy owing to high detection specificities, effective ablation, and minimal side‐effects. Herein, a tumor microenvironment (TME)‐activated NIR‐II nanotheranostic system (FEAD1) for precise diagnosis and treatment of peritoneal metastases is presented. FEAD1 was fabricated by self‐assembling the peptide Fmoc‐His, mercaptopropionic‐functionalized Ag <sub>2</sub> S quantum dots (MPA‐Ag <sub>2</sub> S QDs), the chemodrug doxorubicin (DOX), and NIR absorber A1094 into nanoparticles. We show that in healthy tissue, FEAD1 exists in an NIR‐II fluorescence “off” state, because of Ag <sub>2</sub> S QDs‐A1094 interactions, while DOX remains in stealth mode. Upon delivery of FEAD1 to the tumor, the acidic TME triggers its disassembly through breakage of the Fmoc‐His metal coordination and DOX hydrophobic interactions. Release of A1094 switches on Ag <sub>2</sub> S fluorescence, illuminating the tumor, accompanied by burst release of DOX within the tumor tissue, thereby achieving precise tumor theranostics. This TME‐activated theranostic strategy holds great promise for future clinical applications. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > 可活化的治疗系统显示出由于高检测特异性，有效消融和最小副作用而改善肿瘤诊断和治疗的潜力。这里，提出了一种用于精确诊断和治疗腹膜转移的肿瘤微环境（TME） - 活化的NIR-II纳米烷基因体系（FEAD1）。通过自组装肽Fmoc-his，巯基丙基官能化AG来制造FEAD1 <sub> 2 </ sub> S量子点（MPA-AG <sub> 2 </ sub> S QD），Chemodrug Doxorubicin（DOX）和NIR吸收剂A1094进入纳米颗粒。我们表明，在健康的组织中，FEAD1存在于NIR-II荧光“OFF”状态中，因为AG <sub> 2 </ sub> S QDS-A1094交互，而Dox仍处于隐身模式。在将FEAD1递送到肿瘤后，酸性TME通过破碎FMOC-HIS的金属配位和DOX疏水相互作用来触发其拆卸。释放AG上A1094开关 <sub> 2 </ sub> S荧光，照亮肿瘤，伴随着肿瘤组织内DOX的爆发释放，从而实现精确的肿瘤治疗方法。这种TME激活的Theranostic战略对未来的临床应用具有很大的承诺。 </ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-19011/'>《Angewandte Chemie》</a> <b style="margin: 0 2px;">|</b><span>2020年第18期</span><b style="margin: 0 2px;">|</b><span>共5页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ling Sisi&option=202" target="_blank" rel="nofollow">Ling Sisi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yang Xiaohu&option=202" target="_blank" rel="nofollow">Yang Xiaohu;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Li Chunyan&option=202" target="_blank" rel="nofollow">Li Chunyan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Yejun&option=202" target="_blank" rel="nofollow">Zhang Yejun;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yang Hongchao&option=202" target="_blank" rel="nofollow">Yang Hongchao;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chen Guangcun&option=202" target="_blank" rel="nofollow">Chen Guangcun;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Qiangbin&option=202" target="_blank" rel="nofollow">Wang Qiangbin;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>School of Nano-Tech and Nano-BionicsUniversity of Science and Technology of ChinaHefei 230026 P. R. China;</p> <p>School of Nano-Tech and Nano-BionicsUniversity of Science and Technology of ChinaHefei 230026 P. R. China;</p> <p>School of Nano-Tech and Nano-BionicsUniversity of Science and Technology of ChinaHefei 230026 P. R. China;</p> <p>School of Nano-Tech and Nano-BionicsUniversity of Science and Technology of ChinaHefei 230026 P. R. China;</p> <p>School of Nano-Tech and Nano-BionicsUniversity of Science and Technology of ChinaHefei 230026 P. R. China;</p> <p>School of Nano-Tech and Nano-BionicsUniversity of Science and Technology of ChinaHefei 230026 P. R. China;</p> <p>School of Nano-Tech and Nano-BionicsUniversity of Science and Technology of ChinaHefei 230026 P. R. China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1188.html" title="应用化学">应用化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=coordination assembly&option=203" rel="nofollow">coordination assembly;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=nanotheranostics&option=203" rel="nofollow">nanotheranostics;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=second near-infrared window&option=203" rel="nofollow">second near-infrared window;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=tumor metastasis&option=203" rel="nofollow">tumor metastasis;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=tumor microenvironment&option=203" rel="nofollow">tumor microenvironment;</a> </p> <div class="translation"> 机译：协调组件;纳米移位;第二近红外窗;肿瘤转移;肿瘤微环境; 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class="enjiyixqcontent" href="/academic-conference-cn_meeting-43337_thesis/020222760532.html">肿瘤微环境响肽类树状大分子给药系统用于肿瘤治疗的研究</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=潘达艺&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 潘达艺</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=罗奎&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,罗奎</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=顾忠伟&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,顾忠伟</a> <span> <a href="/conference-cn-43337/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 2017中国生物材料大会 </a> <span> <span> . 2017</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020311850161.html">肿瘤微环境触发的多功能纳米材料用于精确控制肿瘤光热和光动力学治疗</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王玲&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 王玲</a> <span> . 2018</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/061204491634.html">适用于肿瘤移植模型非诊断和治疗目的的药敏反应分析方法、分析系统及其应用</a> <b>[P]</b> . <span> 中国专利： CN108982789B </span> <span> . 2021.06.25</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120112916562.html">改善肿瘤缺氧微环境并增强免疫治疗的纳米递药系统</a> <b>[P]</b> . <span> 中国专利： CN112933052A </span> <span> . 2021-06-11</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130417778784.html">Tumor microenvironment of metastasis (TMEM) and uses thereof in diagnosis, prognosis and treatment of tumors</a> <b>[P]</b> . <span> 外国专利：  US8642277B2 </span> <span> . 2014-02-04</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：肿瘤转移微环境（TMEM）及其在肿瘤的诊断，预后和治疗中的用途 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130425684944.html">Tumor Microenvironment of metastasis (TMEM) and uses thereof in diagnosis, prognosis and treatment of tumors</a> <b>[P]</b> . <span> 外国专利：  US2011059470A1 </span> <span> . 2011-03-10</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：肿瘤转移微环境（TMEM）及其在肿瘤的诊断，预后和治疗中的用途 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130437559583.html">RADIOACTIVE MARKED PEPTIDES FOR DIAGNOSIS AND TREATMENT OF BREAST AND BREAST TUMORS AND METASTASIS OF SUCH TUMORS.</a> <b>[P]</b> . <span> 外国专利：  ES2247835T3 </span> <span> . 2006-03-01</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：放射性标记肽，用于乳腺和乳腺肿瘤的诊断和治疗以及此类肿瘤的转移。 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704028162513','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img src="https://cdn.zhangqiaokeyan.com/img/loginclose.png" alt="关闭" onclick="$('.journalsub-pop-up').hide()"> <p class="pardon">抱歉，该期刊暂不可订阅，敬请期待！</p> <p 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