Semiconducting Polymer Dots with Dual‐Enhanced NIR‐IIa Fluorescence for Through‐Skull Mouse‐Brain Imaging

Zhang Zhe; Fang Xiaofeng; Liu Zhihe; Liu Haichao; Chen Dandan; He Shuqing; Zheng Jie; Yang Bing; Qin Weiping; Zhang Xuanjun; Wu Changfeng

摘要

Abstract >Fluorescence probes in the NIR‐IIa region show drastically improved imaging owing to the reduced photon scattering and autofluorescence in biological tissues. Now, NIR‐IIa polymer dots (Pdots) are developed with a dual fluorescence enhancement mechanism. First, the aggregation induced emission of phenothiazine was used to reduce the nonradiative decay pathways of the polymers in condensed states. Second, fluorescence quenching was minimized by different levels of steric hindrance to further boost the fluorescence. The resulting Pdots displayed a fluorescence QY of ca. 1.7?% in aqueous solution, suggesting an enhancement of ca. 21 times in comparison with the original polymer in tetrahydrofuran (THF) solution. Small‐animal imaging by using the NIR‐IIa Pdots exhibited a remarkable improvement in penetration depth and signal to background ratio, as confirmed by through‐skull and through‐scalp fluorescent imaging of the cerebral vasculature of live mice. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > NIR-IIA区域中的荧光探针显示出由于生物组织中的光子散射和自发荧光而显着改善的成像。现在，具有双荧光增强机构的NIR-IIA聚合物点（PDOT）。首先，使用吩噻嗪的聚集诱导的吩噻嗪的发射来减少聚合物中聚合物中的非相互作用衰减途径。其次，通过不同水平的空间障碍物最小化荧光猝灭，以进一步提高荧光。得到的PDOTS显示了CA的荧光Qy。含水溶液中1.7℃，表明CA的增强。与四氢呋喃（THF）溶液中的原始聚合物相比21次。使用NIR-IIA PDOTS的小动物成像表现出显着的渗透深度和信号与背景比的显着改善，通过脑血管系统的通过颅骨和直链荧光成像证实。</ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-19011/'>《Angewandte Chemie》</a> <b style="margin: 0 2px;">|</b><span>2020年第9期</span><b style="margin: 0 2px;">|</b><span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Zhe&option=202" target="_blank" rel="nofollow">Zhang Zhe;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Fang Xiaofeng&option=202" target="_blank" rel="nofollow">Fang Xiaofeng;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liu Zhihe&option=202" target="_blank" rel="nofollow">Liu Zhihe;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liu Haichao&option=202" target="_blank" rel="nofollow">Liu Haichao;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chen Dandan&option=202" target="_blank" rel="nofollow">Chen Dandan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=He Shuqing&option=202" target="_blank" rel="nofollow">He Shuqing;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zheng Jie&option=202" target="_blank" rel="nofollow">Zheng Jie;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yang Bing&option=202" target="_blank" rel="nofollow">Yang Bing;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Qin Weiping&option=202" target="_blank" rel="nofollow">Qin Weiping;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Xuanjun&option=202" target="_blank" rel="nofollow">Zhang Xuanjun;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wu Changfeng&option=202" target="_blank" rel="nofollow">Wu Changfeng;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Biomedical EngineeringSouthern University of Science and TechnologyShenzhen Guangdong 518055 China;</p> <p>Department of Biomedical EngineeringSouthern University of Science and TechnologyShenzhen Guangdong 518055 China;</p> <p>Department of Biomedical EngineeringSouthern University of Science and TechnologyShenzhen Guangdong 518055 China;</p> <p>State Key Laboratory of Integrated OptoelectronicsJilin University ChangchunJilin 130012 China;</p> <p>Department of Biomedical EngineeringSouthern University of Science and TechnologyShenzhen Guangdong 518055 China;</p> <p>Department of Biomedical EngineeringSouthern University of Science and TechnologyShenzhen Guangdong 518055 China;</p> <p>State Key Laboratory of Integrated OptoelectronicsJilin University ChangchunJilin 130012 China;</p> <p>State Key Laboratory of Integrated OptoelectronicsJilin University ChangchunJilin 130012 China;</p> <p>State Key Laboratory of Integrated OptoelectronicsJilin University ChangchunJilin 130012 China;</p> <p>Cancer Centre and Centre of Reproduction Development and Aging Faculty of Health ScienceUniversity of MacauTaipa Macau SAR 999078 China;</p> <p>Department of Biomedical EngineeringSouthern University of Science and TechnologyShenzhen Guangdong 518055 China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1188.html" title="应用化学">应用化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=aggregation-induced emission&option=203" rel="nofollow">aggregation-induced emission;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=molecular engineering&option=203" rel="nofollow">molecular engineering;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=NIR-II fluorescence imaging&option=203" rel="nofollow">NIR-II fluorescence imaging;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=polymer dots&option=203" rel="nofollow">polymer dots;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=semiconducting polymers&option=203" rel="nofollow">semiconducting polymers;</a> </p> <div class="translation"> 机译：聚集诱导的发射;分子工程;NIR-II荧光成像;聚合物点;半导体聚合物; </div> </li> </ul> 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