A Supramolecular‐Based Dual‐Wavelength Phototherapeutic Agent with Broad‐Spectrum Antimicrobial Activity Against Drug‐Resistant Bacteria

Yu Zhi‐Hao; Li Xingshu; Xu Fugui; Hu Xi‐Le; Yan Jiatao; Kwon Nahyun; Chen Guo‐Rong; Tang Tingting; Dong Xiaojing; Mai Yiyong; Chen Daijie; Yoon Juyoung; He Xiao‐Peng; Tian He

摘要

Abstract >With the ever‐increasing threat posed by the multi‐drug resistance of bacteria, the development of non‐antibiotic agents for the broad‐spectrum eradication of clinically prevalent superbugs remains a global challenge. Here, we demonstrate the simple supramolecular self‐assembly of structurally defined graphene nanoribbons (GNRs) with a cationic porphyrin (Pp4N) to afford unique one‐dimensional wire‐like GNR superstructures coated with Pp4N nanoparticles. This Pp4N/GNR nanocomposite displays excellent dual‐modal properties with significant reactive‐oxygen‐species (ROS) production (in photodynamic therapy) and temperature elevation (in photothermal therapy) upon light irradiation at 660 and 808?nm, respectively. This combined approach proved synergistic, providing an impressive antimicrobial effect that led to the complete annihilation of a wide spectrum of Gram‐positive, Gram‐negative, and drug‐resistant bacteria both in?vitro and in?vivo. The study also unveils the promise of GNRs as a new platform to develop dual‐modal antimicrobial agents that are able to overcome antibiotic resistance. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> 凭借细菌多药物抗性的不断增加的威胁，对广谱普遍消除临床普遍存在的超级缺乏的非抗生素药物仍然是全球挑战。这里，我们用阳离子卟啉（PP4N）证明了结构定义的石墨烯纳米纤维（GNR）的简单超分子自组装，得到了涂有PP4N纳米颗粒的独特的一维线状GNR上部结构。该PP4N / GNR纳米复合材料在660和808Ω·NM的光照下，显示出具有明显的反应性 - 氧 - 物种（ROS）生产（在光热疗法）和温度升高（在光热疗法中）的优异的双模性能。这种组合方法证明了协同作用，提供了令人印象深刻的抗微生物效果，导致了在体外和β体外含有广泛的革兰氏阳性，耐药细菌的完全湮灭。该研究还推出了GNR的承诺作为开发能够克服抗生素抗性的双模抗微生物剂的新平台。</ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-19011/'>《Angewandte Chemie》</a> <b style="margin: 0 2px;">|</b><span>2020年第9期</span><b style="margin: 0 2px;">|</b><span>共7页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yu Zhi‐Hao&option=202" target="_blank" rel="nofollow">Yu Zhi‐Hao;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Li Xingshu&option=202" target="_blank" rel="nofollow">Li Xingshu;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Xu Fugui&option=202" target="_blank" rel="nofollow">Xu Fugui;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hu Xi‐Le&option=202" target="_blank" rel="nofollow">Hu Xi‐Le;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yan Jiatao&option=202" target="_blank" rel="nofollow">Yan Jiatao;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kwon Nahyun&option=202" target="_blank" rel="nofollow">Kwon Nahyun;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chen Guo‐Rong&option=202" target="_blank" rel="nofollow">Chen Guo‐Rong;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tang Tingting&option=202" target="_blank" rel="nofollow">Tang Tingting;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Dong Xiaojing&option=202" target="_blank" rel="nofollow">Dong Xiaojing;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mai Yiyong&option=202" target="_blank" rel="nofollow">Mai Yiyong;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chen Daijie&option=202" target="_blank" rel="nofollow">Chen Daijie;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yoon Juyoung&option=202" target="_blank" rel="nofollow">Yoon Juyoung;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=He Xiao‐Peng&option=202" target="_blank" rel="nofollow">He Xiao‐Peng;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tian He&option=202" target="_blank" rel="nofollow">Tian He;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular EngineeringEast China University of Science and Technology130 Meilong RD Shanghai 200237 China;</p> <p>Department of Chemistry and NanoscienceEwha Womans UniversitySeoul 03760 Republic of Korea;</p> <p>School of Chemistry and Chemical EngineeringShanghai Jiao Tong University800 Dongchuan RD Shanghai 200240 China;</p> <p>Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular EngineeringEast China University of Science and Technology130 Meilong RD Shanghai 200237 China;</p> <p>Department of Polymer MaterialsShanghai UniversityShanghai 200444 China;</p> <p>Department of Chemistry and NanoscienceEwha Womans UniversitySeoul 03760 Republic of Korea;</p> <p>Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular EngineeringEast China University of Science and Technology130 Meilong RD Shanghai 200237 China;</p> <p>Shanghai Key Laboratory of Orthopedic ImplantsShanghai Ninth People's HospitalShanghai 200011 China;</p> <p>Shanghai Institute of Pharmaceutical Industry285 Gebaini RD Shanghai 201203 China;</p> <p>School of Chemistry and Chemical EngineeringShanghai Jiao Tong University800 Dongchuan RD Shanghai 200240 China;</p> <p>Shanghai Institute of Pharmaceutical Industry285 Gebaini RD Shanghai 201203 China;</p> <p>Department of Chemistry and NanoscienceEwha Womans UniversitySeoul 03760 Republic of Korea;</p> <p>Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular EngineeringEast China University of Science and Technology130 Meilong RD Shanghai 200237 China;</p> <p>Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular EngineeringEast China University of Science and Technology130 Meilong RD Shanghai 200237 China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1188.html" title="应用化学">应用化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=antimicrobial activity&option=203" rel="nofollow">antimicrobial activity;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=graphene nanoribbons&option=203" rel="nofollow">graphene nanoribbons;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=phototherapy&option=203" rel="nofollow">phototherapy;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=porphyrin&option=203" rel="nofollow">porphyrin;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=supramolecular structures&option=203" rel="nofollow">supramolecular structures;</a> </p> <div class="translation"> 机译：抗微生物活性;石墨烯纳米纤维;光疗法;卟啉;超分子结构; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704028162207.html">A Supramolecular‐Based Dual‐Wavelength Phototherapeutic Agent with Broad‐Spectrum Antimicrobial Activity Against Drug‐Resistant Bacteria</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yu Zhi‐Hao&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Yu Zhi‐Hao,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Li Xingshu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Li Xingshu,</a> <a 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Design, synthesis and SAR studies of new classes of agents to treat drug-resistant bacteria, anthrax and tuberculosis infections.</a> <b>[D] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kabir, Mohd Shahjahan.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Kabir, Mohd Shahjahan. </a> <span>2011</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：第一部分：新的有机合成方法的开发：钯和铜催化的碳-碳，碳-硫，碳-氮和碳-氧键的形成，以及DABCO介导的丙烯酸酯醚和胺的立体有择合成。第二部分新型药物的设计，合成和SAR研究，用于治疗抗药性细菌，炭疽和肺结核感染。</span> </p> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-journal-foreign-pmc_detail_thesis/040004009283.html">In Vitro Activity of DC-159a a New Broad-Spectrum Fluoroquinolone Compared with That of Other Agents against Drug-Susceptible and -Resistant Pneumococci</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Catherine Clark&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Catherine Clark,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kathy Smith&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Kathy Smith,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lois Ednie&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Lois Ednie,</a> <span>2008</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：新型广谱氟喹诺酮DC-159a的体外活性与其他抗药敏和抗药性肺炎链球菌的药物相比</span> </p> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/open-access_resources_thesis/01000131525760.html">Degradable Carbon Dots from Cigarette Smoking with Broad-Spectrum Antimicrobial Activities against Drug-Resistant Bacteria</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> </a> <span>-1</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：来自抗耐药细菌的广谱抗微生物活动的香烟吸烟可降解碳点</span> </p> </li> <li> <div> <b>8. </b><a class="enjiyixqcontent" href="/ntis-science-report_ad_thesis/02071286307.html">Activity of Topical Antimicrobial Agents Against Multidrug-Resistant Bacteria Recovered from Burn Patients.</a> <b>[R] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Glasser, J. S.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Glasser, J. S.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext= Guymon, C. H.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> Guymon, C. H.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext= Mende, K.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> Mende, K.,</a> <span>2010</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：局部抗菌药物对烧伤患者多药耐药细菌的活性。</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_detail_thesis/0201294946335.html">三苯双脒——一种新的广谱抗肠道蠕虫新药</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=肖树华&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 肖树华</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=吴惠敏&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,吴惠敏</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王翀&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,王翀</a> <span> <a href="/journal-cn-57243/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国寄生虫学与寄生虫病杂志 </a> </span> <span> . 2004</span><span>,第5期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_anhui-science-technology_thesis/0201255679637.html">一种具有广谱除草活性的除草剂</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=黄建社&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 黄建社</a> <span> <a href="/journal-cn-5135/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 安徽科技 </a> </span> <span> . 1998</span><span>,第003期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-antibiotics_thesis/0201241571397.html">具有广谱抗菌活性的红树林稀有放线菌的分离及鉴定</a> <b>[J]</b> <span> <a 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href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘秋&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,刘秋</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘限&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,刘限</a> <span> <a href="/journal-cn-7233/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 甘肃农业大学学报 </a> </span> <span> . 2013</span><span>,第002期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_microbiology-china_thesis/0201255202942.html">一株具有广谱抗菌活性小单孢菌的分离和鉴定</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=龙中儿&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 龙中儿</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=朱跃进&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,朱跃进</a> <a 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<div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130415175784.html">"A method for enhancing the effectiveness of at least one antimicrobial agent in reducing or inhibiting microbial growth in an aqueous composition, for providing residual antimicrobial activity to a surface, for preventing or reducing odor from the presence of bacteria or fungi on a surface. mammal, and to provide antimicrobial activity to a film, fiber, molded or extruded article, or composite material made of fibers, polymers, adhesives, and / or plaster, composition, and product. "</a> <b>[P]</b> . <span> 外国专利：  BRPI1011375A2 </span> <span> . 2015-08-25</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：“一种用于增强至少一种抗微生物剂减少或抑制水性组合物中微生物生长，为表面提供残留抗微生物活性，防止或减少表面上细菌或真菌引起的气味的方法。，并为由纤维，聚合物，粘合剂和/或灰泥，组合物和产品制成的膜，纤维，模塑或挤出制品或复合材料提供抗菌活性。” </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130445883445.html">New ureido-substituted dihydropyrimidinone derivatives, useful as broad-spectrum antibacterial agents with strong activity against Gram positive bacteria</a> <b>[P]</b> . <span> 外国专利：  DE10061538A1 </span> <span> . 2002-06-20</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：新的脲基取代的二氢嘧啶酮衍生物，可用作广谱抗菌剂，对革兰氏阳性细菌具有强活性 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130445883442.html">New arylamino-substituted dihydropyrimidinone derivatives, useful as broad-spectrum antibacterial agents with strong activity against Gram positive bacteria</a> <b>[P]</b> . <span> 外国专利：  DE10061541A1 </span> <span> . 2002-06-20</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：新的芳基氨基取代的二氢嘧啶酮衍生物，可用作对革兰氏阳性细菌具有强活性的广谱抗菌剂 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704028162207','4',7,2,1,'',this,24)" class="delivery" 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