Chiral Aluminum Complex Controls Enantioselective Nickel‐Catalyzed Synthesis of Indenes: C?CN Bond Activation

Zhang Tao; Luan Yu‐Xin; Zheng Su‐Juan; Peng Qian; Ye Mengchun

摘要

Abstract > A chiral aluminum complex controlled, enantioselective nickel‐catalyzed domino reaction of aryl nitriles and alkynes proceeding by C?CN bond activation was developed. The reaction provides various indenes, bearing chiral all‐carbon quaternary centers, under mild reaction conditions in yields of 32 to 91?% and ee ?values within the 73–98?% range. The reaction mechanism and aspects of stereocontrol were investigated by DFT calculations. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > 开发了一种手性铝复合物，芳基腈和炔烃催化的Domino反应和C？CN键活化的糖硝基丙酯和炔烃进行。该反应提供各种茚，携带手性的全碳季中心，在温和的反应条件下，产率为32至91μm和 ee </ i> ？73-98？％范围内的值。通过DFT计算研究了立体控制的反应机理和方面。 </ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-19011/'>《Angewandte Chemie》</a> <b style="margin: 0 2px;">|</b><span>2020年第19期</span><b style="margin: 0 2px;">|</b><span>共5页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Tao&option=202" target="_blank" rel="nofollow">Zhang Tao;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Luan Yu‐Xin&option=202" target="_blank" rel="nofollow">Luan Yu‐Xin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zheng Su‐Juan&option=202" target="_blank" rel="nofollow">Zheng Su‐Juan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Peng Qian&option=202" target="_blank" rel="nofollow">Peng Qian;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ye Mengchun&option=202" target="_blank" rel="nofollow">Ye Mengchun;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>State Key Laboratory and Institute of Elemento-Organic ChemistryNankai UniversityTianjin 300071 China;</p> <p>State Key Laboratory and Institute of Elemento-Organic ChemistryNankai UniversityTianjin 300071 China;</p> <p>State Key Laboratory and Institute of Elemento-Organic ChemistryNankai UniversityTianjin 300071 China;</p> <p>State Key Laboratory and Institute of Elemento-Organic ChemistryNankai UniversityTianjin 300071 China;</p> <p>State Key Laboratory and Institute of Elemento-Organic ChemistryNankai UniversityTianjin 300071 China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1188.html" title="应用化学">应用化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=aluminum&option=203" rel="nofollow">aluminum;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=cyclization&option=203" rel="nofollow">cyclization;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=nickel&option=203" rel="nofollow">nickel;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=reaction mechanisms&option=203" rel="nofollow">reaction mechanisms;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=synthetic methods&option=203" rel="nofollow">synthetic methods;</a> </p> <div class="translation"> 机译：铝;环化;镍;反应机制;合成方法; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704028162083.html">Chiral Aluminum Complex Controls Enantioselective Nickel‐Catalyzed Synthesis of Indenes: C?CN Bond Activation</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Tao&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Zhang Tao,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Luan Yu‐Xin&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Luan Yu‐Xin,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zheng Su‐Juan&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Zheng Su‐Juan,</a> <a href="/journal-foreign-19011/" target="_blank" rel="nofollow" class="tuijian_authcolor">Angewandte Chemie .</a> <span>2020</span><span>,第19期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：手性铝复合物对照对映选择性的镍催化合成的茚：C？CN键活化</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-foreign_journal-the-american-chemical-society_thesis/0204111737318.html">Enantioselective Aminomethylamination of Conjugated Dienes with Aminals Enabled by Chiral Palladium Complex-Catalyzed C-N Bond Activation</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yang Liu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Yang Liu,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yinjun Xie&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Yinjun Xie,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hongli Wang&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Hongli Wang,</a> <a href="/journal-foreign-719/" target="_blank" rel="nofollow" class="tuijian_authcolor">Journal of the American Chemical Society .</a> <span>2016</span><span>,第13期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：通过手性钯配合物催化的C-N键活化，共轭二烯与缩醛的对映选择性氨基甲基胺化</span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-foreign_journal-the-american-chemical-society_thesis/0204111821927.html">Key Mechanistic Features of Enantioselective C-H Bond Activation Reactions Catalyzed by [(Chiral Mono-/V-Protected Amino Acid)- Pd(ll)] Complexes</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Djamaladdin G. Musaev&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Djamaladdin G. Musaev,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Alexey Kaledin&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Alexey Kaledin,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bing-Feng Shi&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Bing-Feng Shi,</a> <a href="/journal-foreign-719/" target="_blank" rel="nofollow" class="tuijian_authcolor">Journal of the American Chemical Society .</a> <span>2012</span><span>,第3期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：[（手性单-/ V保护的氨基酸）-Pd（II）]配合物催化的对映选择性C-H键活化反应的关键机理</span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-conference-foreign_meeting-252588_thesis/0705010370162.html">Enantioselective Synthesis of Various Planar-Chiral Metallocenes Catalyzed by Chiral Mo-or Ru-Carbene Complexes</a> <b>[C]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Masamichi Ogasawara&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Masamichi Ogasawara,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Susumu Watanabe&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Susumu Watanabe,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kiyohiko Nakajima&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Kiyohiko Nakajima </a> <a href="/conference-foreign-252588/" target="_blank" rel="nofollow" class="tuijian_authcolor">Symposium on Organometallic Chemistry .</a> <span>2008</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：手性Mo-或Ru- Carbene络合催化的各种平面手性茂金属的对映选择性合成</span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-degree-foreign_mphd_thesis/02061603767.html">Fundamental studies of carbon oxygen bond activation in nickel diphosphine ether complexes and Metallomacrocycles as ligands: Synthesis and characterization of aluminum-bridged bisglyoximato complexes of iron and cobalt.</a> <b>[D] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kelley, Paul.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Kelley, Paul. </a> <span>2014</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：镍二膦醚配合物和金属大环作为配体中碳氧键活化的基础研究：铁和钴的铝桥联双乙氧肟酸酯配合物的合成和表征。</span> </p> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-journal-foreign-pmc_detail_thesis/040005759069.html">Pd(II)-Catalyzed Enantioselective C–H Activation/C–O Bond Formation: Synthesis of Chiral Benzofuranones</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Xiu-Fen Cheng&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Xiu-Fen Cheng,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yan Li&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Yan Li,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yi-Ming Su&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Yi-Ming Su,</a> <span>-1</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：加入pd（II） - 催化的不对称C-H活化/ C-O键的形成：手性苯并呋喃酮的合成</span> </p> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/open-access_resources_thesis/01000129332515.html">Chiral Al-Complex Remote-Controlled Ni-Catalyzed Enantioselective Construction of Indenes</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wenliang Wang&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Wenliang Wang,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jin Xie&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Jin Xie </a> <span>2020</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：手性al-复合遥控的Ni催化诠释的inenenes</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-catalysis_thesis/0201272774115.html">手性布朗斯特酸催化吲哚与氮杂二烯的共轭加成反应对映选择性合成杂三芳基甲烷</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=谢焕平&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 谢焕平</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=吴波&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,吴波</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王新维&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,王新维</a> <span> <a href="/journal-cn-28399/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 催化学报 </a> </span> <span> . 2019</span><span>,第010期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-catalysis_thesis/0201231567086.html">Cu催化吲哚啉的炔丙基烷基化/脱氢对映选择性合成手性N-炔丙基吲哚化合物</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=朱付林&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 朱付林</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=胡向平&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,胡向平</a> <span> <a href="/journal-cn-28399/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 催化学报 </a> </span> <span> . 2015</span><span>,第001期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_journal-east-china-university-science-technology_thesis/0201249529602.html">利用脂肪酶Novozym 435催化转酯反应对映选择性合成(R)-α-硫辛酸的手性前体</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=周伟佳&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 周伟佳</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=郑高伟&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,郑高伟</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陈焕辉&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,陈焕辉</a> <span> <a href="/journal-cn-4622/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 华东理工大学学报（自然科学版） </a> </span> <span> . 2014</span><span>,第001期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-synthetic-chemistry_thesis/0201234505295.html">手性氨基醇(R)-2-氨基-1,1-二苯基-3-(2-萘基)-1-丙醇:制备及其对前手性酮硼烷还原的对映选择性催化作用</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=沈宗旋&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 沈宗旋</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张雅文&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,张雅文</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=顾德本&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,顾德本</a> <span> <a href="/journal-cn-11569/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 合成化学 </a> </span> <span> . 1996</span><span>,第004期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_journal-zhejiang-university-technology_thesis/020128148492.html">MnO2/CNTs电催化剂及其对C—H键的选择性催化活化</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=朱英红&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 朱英红</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李艳芳&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,李艳芳</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=朱颖&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,朱颖</a> <span> <a href="/journal-cn-7434/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 浙江工业大学学报 </a> </span> <span> . 2015</span><span>,第002期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-33552_thesis/02022889226.html">手性金属胶束超分子体系研究:手性脂质性咪唑类配体构成的手性金属胶束催化α-氨基酸酯对映选择性水解反应</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=游劲松&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 游劲松</a> <span> <a href="/conference-cn-33552/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 全国第九届大环化学暨首届超分子化学学术讨论会 </a> <span> <span> . 1998</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020315959095.html">基于铑催化C-H键的活化合成含有苯并呋喃和茚结构的化合物研究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=梅燕乐&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 梅燕乐</a> <span> . 2020</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/061203976591.html">一种铱催化的双向对映选择性合成手性四氢异喹啉的方法</a> <b>[P]</b> . <span> 中国专利： CN107540606B </span> <span> . 2020.09.01</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120100844791.html">一种高对映选择性催化合成手性喹啉酮化合物的方法</a> <b>[P]</b> . <span> 中国专利： CN109970638A </span> <span> . 2019-07-05</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130500462453.html">Enantiomer production method, method for improving enantioselectivity, enantiomer species synthesis control method, enantioselectivity improver, enantioselectivity variable material, enantioselectivity control material, asymmetric synthesis reaction device, complex, and R-form and S How to make a body</a> <b>[P]</b> . <span> 外国专利：  JP6916489B2 </span> <span> . 2021-08-11</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：对映体制备方法，改进对映选择性的方法，对映异构物种合成对照方法，对映选择性改进剂，对映选择性可变材料，对映选择性控制材料，非对称合成反应装置，复合物和R形式，以及如何制作身体 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130407530961.html">Method for producing enantiomers, methods for improving enantioselectivity, enantiomeric species synthesis control methods, enantioselectivity improvers, enantioselectivity variable materials, enantioselective control materials, asymmetric synthesis reactors, complexes, and R and S How to make your body separately</a> <b>[P]</b> . <span> 外国专利：  JPWO2017051856A1 </span> <span> . 2018-07-19</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：对映异构体的制备方法，对映体选择性的改进方法，对映体种类的合成控制方法，对映体选择性改进剂，对映体选择性可变材料，对映体选择性控制材料，不对称合成反应器，配合物以及R和S如何使您的身体分开 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130408949311.html">METHOD FOR PRODUCING ENANTIOMERS, METHOD FOR IMPROVING ENANTIOSELECTIVITY, METHOD FOR CONTROLLING SYNTHESIS OF ENANTIOMER SPECIES, AGENT FOR IMPROVING ENANTIOSELECTIVITY, ENANTIOSELECTIVITY-VARIABLE MATERIAL, ENANTIOSELECTION CONTROLLING MATERIAL, ASYMMETRIC SYNTHESIS REACTION DEVICE, COMPLEX, AND METHOD FOR SEPARATELY PRODUCING R-ISOMER AND S-ISOMER</a> <b>[P]</b> . <span> 外国专利：  WO2017051856A1 </span> <span> . 2017-03-30</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：制备对映体的方法，提高对映体选择性的方法，控制对映体物种合成的方法，用于改进对映体选择性的试剂，对映体选择性的材料，对映体控制材料，不对称合成，合成，反应，反应的结果ISOMER </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704028162083','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img src="https://cdn.zhangqiaokeyan.com/img/loginclose.png" alt="关闭" onclick="$('.journalsub-pop-up').hide()"> <p class="pardon">抱歉，该期刊暂不可订阅，敬请期待！</p> <p class="current">目前支持订阅全部北京大学中文核心（2020）期刊目录。</p> <div style="display: flex;margin-top: 69px;justify-content: space-between;"> <div class="no-sub" onclick="$('.journalsub-pop-up').hide()">暂不订阅</div> <div class="other-sub" onclick="continueSub('from=pc-detail')">继续订阅其他期刊</div> </div> </div> </div> <div class="right_btn"> <ul> <li class="gouwuche">  </li> <li class="yijian"> <a href="javascript:void(0);" onclick="link_analysis('/mycenter/auth/complaint.html',this)" title="意见反馈">意见反馈</a> </li> <li class="top"> <a href="javascript:scrollTo(0,0);" title="回到顶部">回到顶部</a> </li> <li class="shouye"> <a href="/" title="首页">回到首页</a> </li> </ul> </div> <div class="xllindexfooter"> <div class="xllindexfootercenter"> <div class="xllindexfooterleft left" > <div class="xllindexfooterleftli"> <ul> <li><a href="/about.html" title="关于掌桥">关于掌桥</a></li> <li><a href="/help/helpmap.html" title="资源导航">资源导航</a></li> <li><a href="/help/helpguide.html" title="新手指南">新手指南</a></li> <li><a href="/help/helpcenter.html" title="常见问题">常见问题</a></li> <li><a href="/sitemap.html" title="网站地图">网站地图</a></li> <li><a href="/help/helpcenter.html?type=9" title="版权声明">版权声明</a></li> </ul> </div> <div class="xllindexfooterleft"> <p class="xllindexfooterlefteamil">客服邮箱：kefu@zhangqiaokeyan.com</p> <div class="xllindexfooterlefttcp"> <div class="xllindexfooterpoliceiimg"></div> <div class="xllindexfooterpoliceispan"> <span>京公网安备：11010802029741号 </span> <span>ICP备案号：<a href="https://beian.miit.gov.cn" rel="nofollow" target="_blank" title="ICP备案号">京ICP备15016152号-6</a></span> <span>六维联合信息科技 (北京) 有限公司©版权所有</span> </div> </div> </div> </div> <div class="xllindexfooterright left"> <ul> <li> <p style="font-weight: bold;">客服微信</p> <div></div> </li> <li> <p style="font-weight: bold;">服务号</p> <div></div> </li> </ul> </div> </div> </div> <span id="0704028162083down" data-source="7," data-out-id="U+UKZSkyz7SfXeuf7zCO2E4JcqaGjnegZtvJ1fUjaJeFTaT2gBJ60yMBOavuS4b4," data-f-source-id="7" data-title="Chiral Aluminum Complex Controls Enantioselective Nickel‐Catalyzed Synthesis of Indenes: C?CN Bond Activation" data-price="20" data-site-name="" data-transnum="24" style="display:none;"></span> <input type="hidden" value="4" id="sourcetype"> <input type="hidden" value="19011" id="journalid"> <input type="hidden" value="1" id="inyn_provide_service_level"> <input type="hidden" value="https://cdn.zhangqiaokeyan.com" id="imgcdn"> <input type="hidden" value="1" id="isdeatail"> <input type="hidden" value="" id="syyn_indexed_database"> <input type="hidden" value="" id="servicetype"> <input type="hidden" id="pagename" value="Chiral Aluminum Complex Controls Enantioselective Nickel‐Catalyzed Synthesis of Indenes: C?CN Bond Activation"/> <input type="hidden" value="thesis_get_original" id="pageIdentification"> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery-1.12.4.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/lwlh_ajax.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zq.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/common.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery.cookie.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/top.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/tip.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/login.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/down.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/search.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/newmail.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/searchtype.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/user/regist.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zxs_solor/detail.js?v=5.7.8"></script> <script type="text/javascript" src="https://www.zhangqiaokeyan.com/statistics/static/pagecollection.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/tj.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/sse.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/pushbaidu.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/history.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/util/cookie.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/weipu/weipu.js?v=5.7.8"></script> </body> <script> $(function(){ var weiPuStatus = getCookie('WeiPuStatus'); if(weiPuStatus){ tipWeiPuStatus(weiPuStatus); delCookie('WeiPuStatus'); } getFacetKeywordVoInId(); var sourcetype = $("#sourcetype").val(); var inyn_provide_service_level = $("#inyn_provide_service_level").val(); if((sourcetype ==1||sourcetype==4)&&inyn_provide_service_level!=4){ getJournal(); } }) </script> </html>