Poly(2‐Oxazoline)‐Based Functional Peptide Mimics: Eradicating MRSA Infections and Persisters while Alleviating Antimicrobial Resistance

Zhou Min; Qian Yuxin; Xie Jiayang; Zhang Wenjing; Jiang Weinan; Xiao Ximian; Chen Sheng; Dai Chengzhi; Cong Zihao; Ji Zhemin; Shao Ning; Liu Longqiang; Wu Yuequn; Liu Runhui

摘要

Abstract > Peptides have important biological functions. However, their susceptibility to proteolysis limits their applications. We demonstrated here for the first time, that poly(2‐oxazoline) (POX) can work as a functional mimic of peptides. POX‐based glycine pseudopeptides, a host defense peptide mimic, had potent activities against methicillin‐resistant S. aureus , which causes formidable infections. The POX mimic showed potent activity against persisters that are highly resistant to antibiotics. S. aureus did not develop resistance to POX owning to the reactive oxygen species related antimicrobial mechanism. POX‐treated S. aureus is sensitive to common antibiotics, demonstrating no observable antimicrobial pressure or cross‐resistance in using antimicrobial POX. This study highlights POX as a new type of functional mimic of peptides and opens new avenues in designing and exploring peptide mimetics for biological functions and applications. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > 肽具有重要的生物功能。然而，它们对蛋白质溶解的易感性限制了它们的应用。我们首次在此展示，聚（2-恶唑啉）（POX）可以作为肽的功能模拟。基于痘的甘氨酸假肽，一种宿主防毒肽模仿，具有抗甲氧西林的有效的活性 s。金黄色葡萄球菌</ i> ，这导致突起的感染。 POX模拟物显示出对抗生素具有高度抗性的持久性的有效活性。 s。金黄色葡萄球菌</ i> 没有产生对具有反应性氧物种相关抗微生物机制的痘痘的抵抗力。痘治疗 s。金黄色葡萄球菌</ i> 对常见的抗生素敏感，展示了使用抗菌痘的可观察抗微生物压力或交叉抗性。本研究突出了痘作为肽的新型功能模拟，并在设计和探索生物功能和应用中开启新的途径。 </ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-19011/'>《Angewandte Chemie》</a> <b style="margin: 0 2px;">|</b><span>2020年第16期</span><b style="margin: 0 2px;">|</b><span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhou Min&option=202" target="_blank" rel="nofollow">Zhou Min;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Qian Yuxin&option=202" target="_blank" rel="nofollow">Qian Yuxin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Xie Jiayang&option=202" target="_blank" rel="nofollow">Xie Jiayang;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Wenjing&option=202" target="_blank" rel="nofollow">Zhang Wenjing;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jiang Weinan&option=202" target="_blank" rel="nofollow">Jiang Weinan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Xiao Ximian&option=202" target="_blank" rel="nofollow">Xiao Ximian;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chen Sheng&option=202" target="_blank" rel="nofollow">Chen Sheng;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Dai Chengzhi&option=202" target="_blank" rel="nofollow">Dai Chengzhi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Cong Zihao&option=202" target="_blank" rel="nofollow">Cong Zihao;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ji Zhemin&option=202" target="_blank" rel="nofollow">Ji Zhemin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Shao Ning&option=202" target="_blank" rel="nofollow">Shao Ning;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liu Longqiang&option=202" target="_blank" rel="nofollow">Liu Longqiang;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wu Yuequn&option=202" target="_blank" rel="nofollow">Wu Yuequn;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liu Runhui&option=202" target="_blank" rel="nofollow">Liu Runhui;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai 200237 China;</p> <p>State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai 200237 China;</p> <p>State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai 200237 China;</p> <p>State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai 200237 China;</p> <p>State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai 200237 China;</p> <p>State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai 200237 China;</p> <p>State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai 200237 China;</p> <p>State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai 200237 China;</p> <p>State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai 200237 China;</p> <p>State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai 200237 China;</p> <p>State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai 200237 China;</p> <p>State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai 200237 China;</p> <p>State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai 200237 China;</p> <p>State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai 200237 China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1188.html" title="应用化学">应用化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=antibiotics&option=203" rel="nofollow">antibiotics;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=antimicrobials&option=203" rel="nofollow">antimicrobials;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=drug design&option=203" rel="nofollow">drug design;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=peptides&option=203" rel="nofollow">peptides;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=polymers&option=203" rel="nofollow">polymers;</a> </p> <div class="translation"> 机译：抗生素;抗微生物;药物设计;肽;聚合物; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div 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href="/academic-journal-cn_chinese-journal-chromatography_thesis/0201280427345.html">聚(2-甲基-2-口恶唑啉)在毛细管电泳分离蛋白质中的应用</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王雨晨&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 王雨晨</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王延梅&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,王延梅</a> <span> <a href="/journal-cn-14390/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 色谱 </a> </span> <span> . 2020</span><span>,第009期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-chromatography_thesis/0201280427352.html">基于聚(2-甲基-2-口恶唑啉)和聚丙烯酸的混合刷在毛细管电泳在线富集溶菌酶中的应用</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张淼&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 张淼</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王雨晨&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,王雨晨</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=MUHAMMAD Atif&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,MUHAMMAD Atif</a> <span> <a href="/journal-cn-14390/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 色谱 </a> </span> <span> . 2020</span><span>,第009期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_journal-southwest-china-normal-university-natural-science-edition_thesis/0201295953709.html">2-芳酰氨基-5-(5-甲基异(口恶)唑-3-基)-1,3,4-噻二唑及3-(5-甲基异(口恶)唑3-基)-4-芳酰基-1,2,4-三唑啉-5-硫酮的合成</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杨素君&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 杨素君</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=冯小明&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,冯小明</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=但建明&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,但建明</a> <span> <a href="/journal-cn-50471/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 西南师范大学学报：自然科学版 </a> </span> <span> . 1993</span><span>,第4期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chemical-journal-chinese-universities_thesis/0201231626451.html">聚(苯乙烯-b-2-甲基-2-（口恶）唑啉)嵌段共聚物的合成</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘燕飞&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 刘燕飞</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=万小龙&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,万小龙</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=应圣康&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,应圣康</a> <span> <a href="/journal-cn-10958/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 高等学校化学学报 </a> </span> <span> . 2000</span><span>,第007期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-applied-chemistry_thesis/0201272096378.html">3-N-乙酰基-2-取代芳基-5-5′-甲基-异(口恶)唑-3′-Δ3-1,3,4-(口恶)唑啉类化合物的合成</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=钟滨&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 钟滨</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=赵卫光&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,赵卫光</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李正名&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,李正名</a> <span> <a href="/journal-cn-54377/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 应用化学 </a> </span> <span> . 2003</span><span>,第008期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-33266_thesis/02022800176.html">EAA与聚(2-乙基-2恶唑啉)接枝共聚物的合成及表征</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张鹰&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 张鹰</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陈瑞珠&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,陈瑞珠</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张云灿&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,张云灿</a> <span> <a href="/conference-cn-33266/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国化学会'99高分子学术论文报告会 </a> <span> <span> . 1999</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020312688558.html">紫杉醇/聚(2-乙基-2-恶唑啉)(PEtOz)和聚ε-己内酯(PCL)二嵌段共聚物微球的制备及药效学研究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=唐勇&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 唐勇</a> <span> . 2013</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120101984979.html">聚(2-乙基-2-恶唑啉)-脂质衍生物及制备方法</a> <b>[P]</b> . <span> 中国专利： CN103319710A </span> <span> . 2013-09-25</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120102853359.html">抗肿瘤化合物N-(2-(4-氯苯基)-5-恶唑基)-2-(1,3-二氧代-2-异吲哚啉基)乙酰胺的合成方法</a> <b>[P]</b> . <span> 中国专利： CN104177348A </span> <span> . 2014-12-03</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130440125215.html">Method for determining a predisposition and resistance to infection, kit for the diagnosis of a predisposition to infection, vector, use of a vector, composition, use of composition, contraceptive, use of a microbiocide, use of peptide, polypeptide, protein or glycosylation, sulfonation, acetylation derivatives, or other post-translation derivatives, functional derivatives, homologues or fragments of protein, vaccine, use of an encoder, chip or test plate, use of a chip or from an assay plate, use of the d22s929, d22s277, d22s264, d22s423 amp; d22s418 or d22s272 microsatellite loci, complementary nucleic acids or fragments, polymorphisms, publishing variants or homologues of said gene, immunoglobulin a, use of an immunoglobulin a, use of a nucleic acid vaccine, use of a nucleic acid, peptide, polypeptide, or protein, use of a peptide, polypeptide, or protein</a> <b>[P]</b> . <span> 外国专利：  BR0315382A </span> <span> . 2005-08-23</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：确定感染易感性和抵抗力的方法，用于诊断感染易感性的试剂盒，载体，载体的使用，组合物，组合物的使用，避孕，杀菌剂的使用，肽，多肽，蛋白质或糖基化的使用，磺化，乙酰化衍生物或其他翻译后衍生物，蛋白质的功能衍生物，同源物或片段，疫苗，使用编码器，芯片或测试板，使用芯片或来自检测板，d22s929，d22s277， d22s264，d22s423和d22s418或d22s272微卫星基因座，互补核酸或片段，多态性，所述基因的发布变异体或同源物，免疫球蛋白a，免疫球蛋白a的使用，核酸疫苗的使用，核酸，肽的使用，多肽或蛋白质，使用肽，多肽或蛋白质 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130460499068.html">MRSA PBP2', DETECTION OF MRSA INFECTION AND SYNTHETIC PEPTIDE THEREFOR</a> <b>[P]</b> . <span> 外国专利：  JPH05339289A </span> <span> . 1993-12-21</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：MRSA PBP2'，MRSA感染的检测及其合成肽 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130415192771.html">Use of antimicrobial peptides as markers for resistance to bacterial infections in Cameroon peneu00eddeos</a> <b>[P]</b> . <span> 外国专利：  BRPI0718624A2 </span> <span> . 2015-06-16</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：抗菌肽作为抗喀麦隆佩尼细菌感染的标志物的用途 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704028161997','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div 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