Stereocontrolled Synthesis of Model Core Systems of Lomaiviticins A and B

摘要

Lomaiviticins A (1) and B (2,Figure 1) were isolated in 2001 from the fermentation broth of a species of the actinomycete genus Micromonospora.Both natural products were shown to be highly active DNA-damaging agents.The more abundant compound,lomaiviticin A,exhibited extremely potent cytotoxicity against a broad range of cancer cell lines in vitro,with IC_(50) values ranging from 98 to 0.01 ngmL~(-1).The cytotoxicity profile of the lomaiviticins differs significantly from that of other DNA-damaging agents,such as mitomi-cin C and adriamycin,hinting at a possible new mode of action for the former compounds.