Polymer Nanocontainers for Intracellular Delivery

Pottanam Chali Sharafudheen; Ravoo Bart Jan

摘要

Abstract >Carriers for intracellular delivery are required to overcome limitations of therapeutic agents such as low specificity, systemic toxicity, high clearance rate, and low therapeutic index. Nanocontainers comprised of an aqueous core and a polymer shell have received increasing attention because they readily combine stimuli response to improve intracellular payload release and surface modification to enhance selectivity towards the desired region of action. This Minireview summarizes the design and properties of polymer nanocontainers for intracellular delivery, classified according to the polymer architecture. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> 用于细胞内递送的载体是需要克服治疗剂的限制，例如低特异性，全身毒性，高间隙率和低治疗指数。由含水核和聚合物壳组成的纳米容器已经得到了越来越长的关注，因为它们容易结合刺激反应，以改善细胞内有效载荷释放和表面改性，以增强对所需作用区域的选择性。该MINIREVIEW总结了聚合物纳米容器的设计和性质，用于细胞内递送，根据聚合物结构分类。</ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-19011/'>《Angewandte Chemie》</a> <b style="margin: 0 2px;">|</b><span>2020年第8期</span><b style="margin: 0 2px;">|</b><span>共11页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Pottanam Chali Sharafudheen&option=202" target="_blank" rel="nofollow">Pottanam Chali Sharafudheen;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ravoo Bart Jan&option=202" target="_blank" rel="nofollow">Ravoo Bart Jan;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Organic Chemistry Institute and Centre for Soft NanoscienceWestf?lische Wilhelms-Universit?t MünsterCorrensstrasse 40 48149 Münster Germany;</p> <p>Organic Chemistry Institute and Centre for Soft NanoscienceWestf?lische Wilhelms-Universit?t MünsterCorrensstrasse 40 48149 Münster Germany;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1188.html" title="应用化学">应用化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=block copolymers&option=203" rel="nofollow">block copolymers;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=intracellular delivery&option=203" rel="nofollow">intracellular delivery;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=polymer nanocontainers&option=203" rel="nofollow">polymer nanocontainers;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=stimuli-responsive materials&option=203" rel="nofollow">stimuli-responsive materials;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=vesicles&option=203" rel="nofollow">vesicles;</a> </p> <div class="translation"> 机译：嵌段共聚物;细胞内递送;聚合物纳米细胞;刺激反应材料;囊泡; 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