Nickel/Photoredox-Catalyzed Asymmetric Reductive Cross-Coupling of Racemic alpha-Chloro Esters with Aryl Iodides

摘要

A unique nickel/organic photoredox co-catalyzed asymmetric reductive cross-coupling between alpha-chloro esters and aryl iodides is developed. This cross-electrophile coupling reaction employs an organic reductant (Hantzsch ester), whereas most reductive cross-coupling reactions use stoichiometric metals. A diverse array of valuable alpha-aryl esters is formed under these conditions with high enantioselectivities (up to 94 %) and good yields (up to 88 %). alpha-Aryl esters represent an important family of nonsteroidal anti-inflammatory drugs. This novel synergistic strategy expands the scope of Ni-catalyzed reductive asymmetric cross-coupling reactions.