Programmable Assembly of Nano‐architectures through Designing Anisotropic DNA Origami Patches

Wang Mingyang; Dai Lizhi; Duan Jialin; Ding Zhiyuan; Wang Peng; Li Zheng; Xing Hang; Tian Ye

摘要

Abstract >Programmable assembly of nanoparticles (NPs) into well‐defined architectures has attracted attention because of tailored properties resulting from coupling effects. However, general and precise approaches to control binding modes between NPs remain a challenge owing to the difficulty in manipulating the accurate positions of the functional patches on the surface of NPs. Here, a strategy is developed to encage spherical NPs into pre‐designed octahedral DNA origami frames (DOFs) through DNA base‐pairings. The DOFs logically define the arrangements of functional patches in three dimensions, owing to the programmability of DNA hybridization, and thus control the binding modes of the caged nanoparticle with designed anisotropy. Applying the node‐and‐spacer approach that was widely used in crystal engineering to design coordination polymers, patchy NPs could be rationally designed with lower symmetry encoded to assemble a series of nano‐architectures with high‐order geometries. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> >纳米颗粒（NPS）的可编程组装成明确定义的架构，因为耦合效应导致的量身定制的属性引起了注意力。然而，由于难以操纵NPS表面上的功能贴片的准确位置，因此在NPS之间控制NPS之间的绑定模式的一般和精确方法仍然是一个挑战。这里，通过DNA碱基配对开发了一种策略以将球形NP送入预先设计的八面体DNA折纸（DOF）。由于DNA杂交的可编程性，DOF逻辑地定义了三维功能贴片的布置，从而控制笼养纳米粒子的结合模式，具有设计的各向异性。应用广泛用于设计协调聚合物的节点和间隔方法，拼凑的NPS可以合理地设计，具有较低对称性的编码，以组装一系列具有高阶几何形状的纳米体系结构。</ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-19011/'>《Angewandte Chemie》</a> <b style="margin: 0 2px;">|</b><span>2020年第16期</span><b style="margin: 0 2px;">|</b><span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Mingyang&option=202" target="_blank" rel="nofollow">Wang Mingyang;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Dai Lizhi&option=202" target="_blank" rel="nofollow">Dai Lizhi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Duan Jialin&option=202" target="_blank" rel="nofollow">Duan Jialin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ding Zhiyuan&option=202" target="_blank" rel="nofollow">Ding Zhiyuan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Peng&option=202" target="_blank" rel="nofollow">Wang Peng;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Li Zheng&option=202" target="_blank" rel="nofollow">Li Zheng;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Xing Hang&option=202" target="_blank" rel="nofollow">Xing Hang;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tian Ye&option=202" target="_blank" rel="nofollow">Tian Ye;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>College of Engineering and Applied SciencesNanjing UniversityNanjing 210093 China;</p> <p>College of Engineering and Applied SciencesNanjing UniversityNanjing 210093 China;</p> <p>National Facility for Protein Science in ShanghaiZhangjiang LabShanghai 201210 China;</p> <p>College of Engineering and Applied SciencesNanjing UniversityNanjing 210093 China;</p> <p>College of Engineering and Applied SciencesNanjing UniversityNanjing 210093 China;</p> <p>School of Materials Science and EngineeringXiangtan UniversityXiangtan 411105 China;</p> <p>Institute of Chemical Biology and NanomedicineHunan UniversityChangsha 410082 China;</p> <p>College of Engineering and Applied SciencesNanjing UniversityNanjing 210093 China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1188.html" title="应用化学">应用化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=DNA nanotechnology&option=203" rel="nofollow">DNA nanotechnology;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=DNA origami&option=203" rel="nofollow">DNA origami;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=DNA structures&option=203" rel="nofollow">DNA structures;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Nanoparticles&option=203" rel="nofollow">Nanoparticles;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Self-assembly&option=203" rel="nofollow">Self-assembly;</a> </p> <div class="translation"> 机译：DNA纳米技术;DNA折纸;DNA结构;纳米颗粒;自组装; 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href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=湛鹏飞&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 湛鹏飞</a> <span> . 2014</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/061204944460.html">基于表面增强拉曼效应的DNA折纸模板组装纳米金立方形成二聚体结构的方法</a> <b>[P]</b> . <span> 中国专利： CN110057806B </span> <span> . 2022.03.04</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120112118228.html">一种基于量子点与DNA折纸纳米共组装结构的超分辨显微标尺</a> <b>[P]</b> . <span> 中国专利： CN112129788A </span> <span> . 2020-12-25</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130403460875.html">DNA ORIGAMI NANOPARTICLE DELIVERY OF PROGRAMMED CHROMOSOME BREAKAGE MACHINERY</a> <b>[P]</b> . <span> 外国专利：  WO2019126627A1 </span> <span> . 2019-06-27</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：程序设计的染色体断裂机器的DNA折纸纳米粒子交付 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130438716876.html">METHOD FOR DESIGNING ASSEMBLY CONFIGURATION, PROGRAM FOR DESIGNING ASSEMBLY CONFIGURATION, RECORDING MEDIUM FOR RECORDING THE PROGRAM, AND APPARATUS FOR DESIGNING ASSEMBLY CONFIGURATION</a> <b>[P]</b> . <span> 外国专利：  JP2006072571A </span> <span> . 2006-03-16</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：用于设计组件配置的方法，用于设计组件配置的程序，用于记录该程序的记录介质以及用于设计组件配置的设备 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130499843274.html">DNA origami nanostructures for treatment of acute kidney injury</a> <b>[P]</b> . <span> 外国专利：  US10987373B2 </span> <span> . 2021-04-27</span> </div> <p class="zwjiyix translation" 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