Divergent Biomimetic Total Syntheses of Ganocins?A–C, Ganocochlearins?C and D, and Cochlearol?T

Shao Hui; Gao Xiaonan; Wang Zhong‐Tian; Gao Ziwei; Zhao Yu‐Ming

摘要

Abstract > A divergent synthetic approach to six Ganoderma meroterpenoids, namely ganocins?A–C, ganocochlearins?C and D, and cochlearol?T, has been developed for the first time. This synthetic route features a two‐phase strategy which includes early‐stage rapid construction of a common planar tricyclic intermediate followed by highly selective late‐stage transformations into various Ganoderma meroterpenoids. Key to the strategy are a bioinspired intramolecular hetero‐Diels–Alder reaction and Stahl‐type oxidative aromatization, allowing efficient formation of the common tricyclic phenol intermediate. A nucleophilic dearomatization of the phenol unit, combined with a regioselective 1,4‐reduction of the resulting dienone, enabled rapid access to ganocins?B and C. Additionally, site‐selective Mukaiyama hydration, followed by an intramolecular oxa ‐Michael addition/triflation cascade, served as a key strategic element in the chemical synthesis of ganocin?A. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > 六个发散的合成方法 ganoderma </ i> 梅托萜类化合物，即青霉素？A-C，Ganocochlearins？C和D，以及耳素醇？T，首次开发。这种合成路线具有两相策略，包括普通平面三环中间体的早期快速结构，然后是高度选择性的后期变换成各种 ganoderma </ i> 梅特萜类化合物。该策略的关键是生物悬浮的分子内杂蛋白 - 桤木反应和稳定性氧化芳族化，允许有效地形成普通三环酚中间体。酚类单位的亲核亲胚，与所得的子酮的焦点1,4-还原结合，使得能够快速进入青霉素？B和C.另外，位点选择性Mukaiyama水合，其次是分子内 Oxa </ i> -Michael加法/三级级联，作为青霉素化学合成中的关键战略元素？a。 </ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-19011/'>《Angewandte Chemie》</a> <b style="margin: 0 2px;">|</b><span>2020年第19期</span><b style="margin: 0 2px;">|</b><span>共6页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Shao Hui&option=202" target="_blank" rel="nofollow">Shao Hui;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gao Xiaonan&option=202" target="_blank" rel="nofollow">Gao Xiaonan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Zhong‐Tian&option=202" target="_blank" rel="nofollow">Wang Zhong‐Tian;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gao Ziwei&option=202" target="_blank" rel="nofollow">Gao Ziwei;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhao Yu‐Ming&option=202" target="_blank" rel="nofollow">Zhao Yu‐Ming;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Key Laboratory of Applied Surface and Colloid Chemistry &</p> <p>School of Chemistry and Chemical EngineeringShaanxi Normal University620 West Chang'an Ave Xi'an 710119 China;</p> <p>Key Laboratory of Applied Surface and Colloid Chemistry &</p> <p>School of Chemistry and Chemical EngineeringShaanxi Normal University620 West Chang'an Ave Xi'an 710119 China;</p> <p>Key Laboratory of Applied Surface and Colloid Chemistry &</p> <p>School of Chemistry and Chemical EngineeringShaanxi Normal University620 West Chang'an Ave Xi'an 710119 China;</p> <p>Key Laboratory of Applied Surface and Colloid Chemistry &</p> <p>School of Chemistry and Chemical EngineeringShaanxi Normal University620 West Chang'an Ave Xi'an 710119 China;</p> <p>Key Laboratory of Applied Surface and Colloid Chemistry &</p> <p>School of Chemistry and Chemical EngineeringShaanxi Normal University620 West Chang'an Ave Xi'an 710119 China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1188.html" title="应用化学">应用化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=biomimetic synthesis&option=203" rel="nofollow">biomimetic synthesis;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=cycloaddition&option=203" rel="nofollow">cycloaddition;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=natural products&option=203" rel="nofollow">natural products;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=terpenoids&option=203" rel="nofollow">terpenoids;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=total synthesis&option=203" rel="nofollow">total synthesis;</a> </p> <div class="translation"> 机译：仿生合成;环加成;天然产品;萜件;总合成; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704028161306.html">Divergent Biomimetic Total Syntheses of Ganocins?A–C, Ganocochlearins?C and D, and Cochlearol?T</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Shao Hui&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Shao Hui,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gao Xiaonan&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Gao Xiaonan,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Zhong‐Tian&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Wang Zhong‐Tian,</a> <a href="/journal-foreign-19011/" target="_blank" rel="nofollow" class="tuijian_authcolor">Angewandte Chemie .</a> <span>2020</span><span>,第19期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：嗜酸锰的发散仿生合成α-C，Ganocochlearins？C和D，和耳蜗？T.</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-foreign_journal-the-american-chemical-society_thesis/0204111779161.html">Total Syntheses of (-)-Kopsifoline D and (-)-Deoxoapodine: Divergent Total Synthesis via Late-Stage Key Strategic Bond Formation</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kiyoun Lee&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Kiyoun Lee,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Dale L. Boger&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Dale L. Boger </a> <a href="/journal-foreign-719/" target="_blank" rel="nofollow" class="tuijian_authcolor">Journal of the American Chemical Society .</a> <span>2014</span><span>,第8期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：（-）-Kopsifoline D和（-）-脱氧阿泊定的总合成：通过后期关键战略债券形成不同的总合成。</span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704019230698.html">Intermolecular Radical Cation Diels-Alder (RCDA) Reaction of Bicyclooctadienes: Biomimetic Formal Total Synthesis of Kingianin A and Total Syntheses of Kingianins D, F, H, and J</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hee Nam Lim&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Hee Nam Lim,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kathlyn A. Parker&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Kathlyn A. Parker </a> <a href="/journal-foreign-30984/" target="_blank" rel="nofollow" class="tuijian_authcolor">The Journal of Organic Chemistry .</a> <span>2014</span><span>,第3期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：双环辛二烯的分子间自由基阳离子Diels-Alder（RCDA）反应：金仿宁A的仿生形式全合成和金仿宁D，F，H和J的总合成</span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-conference-foreign_meeting-289454_thesis/0705016517258.html">Divergent Syntheses and Biological Evaluations of New ArtificialGlutamate Analogs</a> <b>[C]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Shuntaro Tsukamoto&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Shuntaro Tsukamoto,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Raku Irie&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Raku Irie,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Masato Oikawa&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Masato Oikawa </a> <a href="/conference-foreign-289454/" target="_blank" rel="nofollow" class="tuijian_authcolor">日本化学会春季年会 .</a> <span>2020</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：新的人为甘氨酸类似物的分歧合成和生物学评价</span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-degree-foreign_mphd_thesis/02061714.html">Synthetic studies of the Thio-Nazarov Cyclization Biomimetic Total Syntheses of Shimalactones and Exiguamines Synthesis of Photoswitchable Dopamine Analogs.</a> <b>[D] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sofiyev, Vladimir.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Sofiyev, Vladimir. </a> <span>2010</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：巯基内酯和Exiguamines的Thio-Nazarov环化仿生总合成的合成研究。</span> </p> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-journal-foreign-pmc_detail_thesis/040005504948.html">Biomimetic Total Syntheses of (−)-Leucoridines A and C through the Dimerization of (−)-Dihydrovalparicine</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Praveen Kokkonda&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Praveen Kokkonda,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Keaon R. Brown&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Keaon R. Brown,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Trevor J. Seguin&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Trevor J. Seguin,</a> <span>-1</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：通过（-）-Dihydrovalparicine的二聚作用仿生全合成（-）-Leucoridines A和C</span> </p> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/open-access_resources_thesis/01000132323420.html">Biomimetic Dehydrogenative Diels-Alder Cycloadditions: Total Syntheses of Brosimones A and B</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chao Qi&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Chao Qi,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Huan Cong&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Huan Cong,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Katharine J. Cahill&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Katharine J. Cahill,</a> <span>2013</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：仿生脱氢Diels-Alder环加入：呋塞酮A和B的总合成</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_guangdong-chemical-industry_thesis/0201290233498.html">镉、锰、镍、铅对嗜酸氧化亚铁硫杆菌活性的影响</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=卓文康&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 卓文康</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=苏文瑶&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,苏文瑶</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王淡君&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,王淡君</a> <span> <a href="/journal-cn-9122/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 广东化工 </a> </span> <span> . 2021</span><span>,第010期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chemistry-bioengineering_thesis/0201246607927.html">一种新型仿生化合物四甲基四(1,4-二噻(口英)四氮杂卟啉锰的合成与表征</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王亚娟&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 王亚娟</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杨昌军&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,杨昌军</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=孙杰&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,孙杰</a> <span> <a href="/journal-cn-9126/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 化学与生物工程 </a> </span> <span> . 2007</span><span>,第009期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_nonferrous-metals-science-engineering_thesis/0201219927007.html">嗜酸氧化亚铁硫杆菌和嗜酸氧化硫硫杆菌联合浸出高锡多金属硫化矿</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王明伟&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 王明伟</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘元东&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,刘元东</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=梁嘉琦&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,梁嘉琦</a> <span> <a href="/journal-cn-7995/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 有色金属科学与工程 </a> </span> <span> . 2018</span><span>,第003期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_nonferrous-metals-science-engineering_thesis/0201272191467.html">嗜酸氧化亚铁硫杆菌和嗜酸氧化硫硫杆菌联合浸出高锡多金属硫化矿</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王明伟12&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 王明伟12</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=梁嘉琦12&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,梁嘉琦12</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=曾伟民12&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,曾伟民12</a> <span> <a href="/journal-cn-22444/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 有色金属科学与工程 </a> </span> <span> . 2018</span><span>,第3)期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_china-dairy-industry_thesis/020124990052.html">新工艺制备高效嗜酸菌发酵剂和嗜酸菌奶粉的研究</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=方景泉&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 方景泉</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=徐欣&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,徐欣</a> <span> <a href="/journal-cn-9434/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国乳品工业 </a> </span> <span> . 2013</span><span>,第007期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-26727_thesis/020221691111.html">锰卟啉仿生催化氧化环己烷合成己二酸反应条件的研究</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陈一霞&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 陈一霞</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=佘远斌&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,佘远斌</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李艳&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,李艳</a> <span> <a href="/conference-cn-26727/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国化学会第九届全国应用化学年会 </a> <span> <span> . 2005</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020312685147.html">烟酰胺腺嘌呤二核苷酸和XIAP基因对新生大鼠耳蜗锰毒性保护作用的研究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王璐&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 王璐</a> <span> . 2014</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120106407788.html">来自酸热脂环酸杆菌的嗜热的与嗜热嗜酸的代谢基因和酶以及相关生物</a> <b>[P]</b> . <span> 中国专利： CN102216451A </span> <span> . 2011-10-12</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120106232546.html">来自酸热脂环酸杆菌的嗜热的与嗜热嗜酸的糖基化基因和酶以及相关生物、方法</a> <b>[P]</b> . <span> 中国专利： CN102046802A </span> <span> . 2011-05-04</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130475030822.html">Optical sensor for detecting change in fluidic optical medium - has transmitting and receiving optical fibres directed to provide divergent beam through medium to totally reflecting prism</a> <b>[P]</b> . <span> 外国专利：  FR2512551A1 </span> <span> . 1983-03-11</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：用于检测流体光学介质变化的光学传感器-具有发送和接收光纤的方向，旨在通过介质提供发散光束到全反射棱镜 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130434866634.html">COMPOSITE BIOMIMETIC TOTAL INTERVERTEBRAL DISC PROSTHESIS</a> <b>[P]</b> . <span> 外国专利：  WO2007007284A3 </span> <span> . 2007-10-11</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：复合生物假体全椎间盘假体 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130434866635.html">COMPOSITE BIOMIMETIC TOTAL INTERVERTEBRAL DISC PROSTHESIS</a> <b>[P]</b> . <span> 外国专利：  WO2007007284A2 </span> <span> . 2007-01-18</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：复合生物假体全椎间盘假体 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704028161306','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img src="https://cdn.zhangqiaokeyan.com/img/loginclose.png" alt="关闭" onclick="$('.journalsub-pop-up').hide()"> <p class="pardon">抱歉，该期刊暂不可订阅，敬请期待！</p> <p class="current">目前支持订阅全部北京大学中文核心（2020）期刊目录。</p> <div style="display: flex;margin-top: 69px;justify-content: space-between;"> <div class="no-sub" onclick="$('.journalsub-pop-up').hide()">暂不订阅</div> <div class="other-sub" onclick="continueSub('from=pc-detail')">继续订阅其他期刊</div> </div> </div> </div> <div class="right_btn"> <ul> <li class="gouwuche">  </li> <li class="yijian"> <a href="javascript:void(0);" onclick="link_analysis('/mycenter/auth/complaint.html',this)" title="意见反馈">意见反馈</a> </li> <li class="top"> <a href="javascript:scrollTo(0,0);" title="回到顶部">回到顶部</a> </li> <li class="shouye"> <a href="/" title="首页">回到首页</a> </li> </ul> </div> <div class="xllindexfooter"> <div class="xllindexfootercenter"> <div class="xllindexfooterleft left" > <div class="xllindexfooterleftli"> <ul> <li><a href="/about.html" title="关于掌桥">关于掌桥</a></li> <li><a href="/help/helpmap.html" title="资源导航">资源导航</a></li> <li><a href="/help/helpguide.html" title="新手指南">新手指南</a></li> <li><a href="/help/helpcenter.html" title="常见问题">常见问题</a></li> <li><a href="/sitemap.html" title="网站地图">网站地图</a></li> <li><a href="/help/helpcenter.html?type=9" title="版权声明">版权声明</a></li> </ul> </div> <div class="xllindexfooterleft"> <p class="xllindexfooterlefteamil">客服邮箱：kefu@zhangqiaokeyan.com</p> <div class="xllindexfooterlefttcp"> <div class="xllindexfooterpoliceiimg"></div> <div class="xllindexfooterpoliceispan"> <span>京公网安备：11010802029741号 </span> <span>ICP备案号：<a href="https://beian.miit.gov.cn" rel="nofollow" target="_blank" title="ICP备案号">京ICP备15016152号-6</a></span> <span>六维联合信息科技 (北京) 有限公司©版权所有</span> </div> </div> </div> </div> <div class="xllindexfooterright left"> <ul> <li> <p style="font-weight: bold;">客服微信</p> <div></div> </li> <li> <p style="font-weight: bold;">服务号</p> <div></div> </li> </ul> </div> </div> </div> <span id="0704028161306down" data-source="7," data-out-id="YDpvIfqziu7XMcfMGmlYpshFCS/JpjIERyb4tLR2Jomfov+gihRUeJ58zGwkX/bc," data-f-source-id="7" data-title="Divergent Biomimetic Total Syntheses of Ganocins?A–C, Ganocochlearins?C and D, and Cochlearol?T" data-price="20" data-site-name="" data-transnum="24" style="display:none;"></span> <input type="hidden" value="4" id="sourcetype"> <input type="hidden" value="19011" id="journalid"> <input type="hidden" value="1" id="inyn_provide_service_level"> <input type="hidden" value="https://cdn.zhangqiaokeyan.com" id="imgcdn"> <input type="hidden" value="1" id="isdeatail"> <input type="hidden" value="" id="syyn_indexed_database"> <input type="hidden" value="" id="servicetype"> <input type="hidden" id="pagename" value="Divergent Biomimetic Total Syntheses of Ganocins?A–C, Ganocochlearins?C and D, and Cochlearol?T"/> <input type="hidden" value="thesis_get_original" id="pageIdentification"> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery-1.12.4.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/lwlh_ajax.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zq.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/common.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery.cookie.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/top.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/tip.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/login.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/down.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/search.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/newmail.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/searchtype.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/user/regist.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zxs_solor/detail.js?v=5.7.8"></script> <script type="text/javascript" src="https://www.zhangqiaokeyan.com/statistics/static/pagecollection.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/tj.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/sse.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/pushbaidu.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/history.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/util/cookie.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/weipu/weipu.js?v=5.7.8"></script> </body> <script> $(function(){ var weiPuStatus = getCookie('WeiPuStatus'); if(weiPuStatus){ tipWeiPuStatus(weiPuStatus); delCookie('WeiPuStatus'); } getFacetKeywordVoInId(); var sourcetype = $("#sourcetype").val(); var inyn_provide_service_level = $("#inyn_provide_service_level").val(); if((sourcetype ==1||sourcetype==4)&&inyn_provide_service_level!=4){ getJournal(); } }) </script> </html>