Stereoinvertive C–C Bond Formation at the Boron‐Bound Stereogenic Centers through Copper‐Bipyridine‐Catalyzed Intramolecular Coupling of α‐Aminobenzylboronic Esters

Yoshinaga Yukako; Yamamoto Takeshi; Suginome Michinori

摘要

Abstract >Enantiospecific intramolecular Suzuki–Miyaura‐type coupling with α‐(2‐halobenzoylamino)benzylboronic esters to give 3‐substituted isoindolinones is achieved by using copper catalysts with 2,2′‐bipyridine‐based achiral ligands. Enantioenriched α‐aminobenzylboron reactants bearing a hydrogen atom at the boron‐bound stereogenic carbons undergo stereoinvertive coupling in the presence of a 6‐phenyl‐2,2′‐bipyridine ligand with high enantiospecificity. α‐Aminobenzylboronates bearing fully substituted boron‐bound stereogenic centers also gave the 3,3‐disubstituted isoindolinones with stereospecific stereochemical inversion in the presence of simple 2,2′‐bipyridine as a ligand. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> 用铜催化剂用铜催化剂与基于2,2'-吡啶基的成分配体的铜催化剂实现了与α-（2-卤硼库酰氨基）苄基硼烯酮的鉴定性分子内的偶联与α-（2-卤苯甲酰芳基酰氨基）苄溴胺偶联。在硼结合的立体碳中携带氢原子的对氨基化α-氨基苄酰基反应物在具有高对抗性的6苯基-2,2'-硼吡啶配体的存在下进行立体性综合偶联。 α-氨基苄基硼酸盐轴承完全取代的硼 - 结合的立体导致患者也使3,3-二取代的异吲哚啉酮在简单的2,2'-双吡啶作为配体存在下具有立体立体化学倒置。</ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-19011/'>《Angewandte Chemie》</a> <b style="margin: 0 2px;">|</b><span>2020年第18期</span><b style="margin: 0 2px;">|</b><span>共5页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yoshinaga Yukako&option=202" target="_blank" rel="nofollow">Yoshinaga Yukako;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yamamoto Takeshi&option=202" target="_blank" rel="nofollow">Yamamoto Takeshi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Suginome Michinori&option=202" target="_blank" rel="nofollow">Suginome Michinori;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Synthetic Chemistry and Biological ChemistryKyoto University Katsura Nishikyo-kuKyoto 615-8510 Japan;</p> <p>Department of Synthetic Chemistry and Biological ChemistryKyoto University Katsura Nishikyo-kuKyoto 615-8510 Japan;</p> <p>Department of Synthetic Chemistry and Biological ChemistryKyoto University Katsura Nishikyo-kuKyoto 615-8510 Japan;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1188.html" title="应用化学">应用化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=bipyridine ligand&option=203" rel="nofollow">bipyridine ligand;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=carbon stereocenters&option=203" rel="nofollow">carbon stereocenters;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=copper&option=203" rel="nofollow">copper;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=enantiospecificity&option=203" rel="nofollow">enantiospecificity;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=stereospecific reaction&option=203" rel="nofollow">stereospecific reaction;</a> </p> <div class="translation"> 机译：Biphyridine配体;碳封闭物;铜;对抗性;立体化反应; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704028161274.html">Stereoinvertive C–C Bond Formation at the Boron‐Bound Stereogenic Centers through Copper‐Bipyridine‐Catalyzed Intramolecular Coupling of α‐Aminobenzylboronic Esters</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yoshinaga Yukako&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Yoshinaga Yukako,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yamamoto Takeshi&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Yamamoto Takeshi,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Suginome Michinori&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Suginome Michinori </a> <a href="/journal-foreign-19011/" target="_blank" rel="nofollow" class="tuijian_authcolor">Angewandte Chemie .</a> <span>2020</span><span>,第18期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：通过α-氨基苄基硼酸酯的铜 - Bi0吡啶催化分子内偶联的硼 - 硼丙氨酸催化的分子分子结合立体助剂C-C键形成</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704018296439.html">Construction of Quaternary Stereogenic Carbon Centers through Copper-Catalyzed Enantioselective Allylic Cross-Coupling with Alkylboranes</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kentaro Hojoh&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Kentaro Hojoh,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yoshinori Shido&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Yoshinori Shido,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hirohisa Ohmiya&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Hirohisa Ohmiya </a> <a href="/journal-foreign-19011/" target="_blank" rel="nofollow" class="tuijian_authcolor">Angewandte Chemie .</a> <span>2014</span><span>,第19期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：铜催化的对映选择性烯丙基与烷基酮的交叉偶联构筑第四立体立体碳中心</span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704018295942.html">Construction of Quaternary Stereogenic Carbon Centers through Copper-Catalyzed Enantioselective Allylic Cross-Coupling with Alkylboranes</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kentaro Hojoh&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Kentaro Hojoh,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yoshinori Shido&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Yoshinori Shido,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hirohisa Ohmiya&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Hirohisa Ohmiya </a> <a href="/journal-foreign-19011/" target="_blank" rel="nofollow" class="tuijian_authcolor">Angewandte Chemie .</a> <span>2014</span><span>,第19期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：铜催化的对映选择性烯丙基与烷基酮的交叉偶联构筑第四立体立体碳中心</span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-conference-foreign_meeting-289454_thesis/0705016517267.html">Enantioconvergent Intramolecular Coupling ofα-Aminobenzylboronic Esters Using Copper-Bipyridine-BasedHelically Chiral Polymer Catalysts</a> <b>[C]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yukako Yoshinaga&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Yukako Yoshinaga,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=TakeshiYamamoto&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">TakeshiYamamoto,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Michinori Suginome&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Michinori Suginome </a> <a href="/conference-foreign-289454/" target="_blank" rel="nofollow" class="tuijian_authcolor">日本化学会春季年会 .</a> <span>2020</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：α-氨基苄基硼酸酯使用铜 - Bi0吡啶基的细胞丙烯酸酯的对映炎素分子内偶联性催化剂</span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-degree-foreign_mphd_thesis/02061707645.html">Catalytic enantioselective synthesis of O-and N-substituted quaternary carbon stereogenic centers: 1. Aluminum-catalyzed alkylations of alpha-ketoesters with dialkylzinc reagents. 2. Silver-catalyzed vinylogous Mannich-type reactions of alpha-ketoimine esters with siloxyfurans</a> <b>[D] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wieland, Laura Caroline&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Wieland, Laura Caroline </a> <span>2008</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：O和N取代的季碳立构中心的催化对映选择性合成：1.用二烷基锌试剂进行铝催化的α-酮酸酯的烷基化。 2.α-酮亚胺酯与甲硅烷氧基呋喃的银催化乙烯基曼尼希型反应</span> </p> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-journal-foreign-pmc_detail_thesis/040005654515.html">Enantioselective Synthesis of Boron-Substituted Quaternary Carbon Stereogenic Centers through NHC–Catalyzed Conjugate Additions of (Pinacolato)boron Units to Enones</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Prof. Suttipol Radomkit&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Prof. Suttipol Radomkit,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Prof. Amir H. Hoveyda&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Prof. Amir H. Hoveyda </a> <span>-1</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：通过NHC催化的（Pinacolato）硼单元与烯酮的共轭加成反应对硼取代的季碳立体异构中心进行对映选择性合成。</span> </p> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/open-access_resources_thesis/01000133068740.html">Stereoinvertive C–C Bond Formation at the Boron‐Bound Stereogenic Centers through Copper‐Bipyridine‐Catalyzed Intramolecular Coupling of α‐Aminobenzylboronic Esters</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yukako Yoshinaga&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Yukako Yoshinaga,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Takeshi Yamamoto&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Takeshi Yamamoto,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Michinori Suginome&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Michinori Suginome </a> <span>2020</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：通过α-氨基苄硼硼酸酯的铜 - Bi0赖氨酸催化分子内偶联在硼结合的立体中的立体助性C-C键形成</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chemical-journal-chinese-universities_thesis/0201231648916.html">分子内反应与分子内催化(Ⅳ)——羟基诱导效应对分子内苯并咪唑基一般碱催化3-(2′-苯并咪唑基)-3-羟基丙酸乙酯水解的影响</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=夏道宏&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 夏道宏</a> <span> <a href="/journal-cn-10958/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 高等学校化学学报 </a> </span> <span> . 1994</span><span>,第010期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_acta-chimica-sinica_thesis/0201296430189.html">分子内反应与分子内催化 Ⅰ.分子内苯并咪唑基一般碱催化2-(2′-苯并咪唑基)乙酸乙酯及3-(2′-苯并咪唑基)丙酸乙酯水解机理的探讨</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=夏炽中&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 夏炽中</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=夏道宏&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,夏道宏</a> <span> <a href="/journal-cn-53859/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 化学学报 </a> </span> <span> . 1990</span><span>,第5期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_journal-shanghai-institute-applied-technology-natural-science-edition_thesis/0201294416025.html">钯(Ⅱ)催化的分子内交叉偶联反应立体选择性合成亚甲基吲哚酮的研究</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=权茂&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 权茂</a> <span> <a href="/journal-cn-53758/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 上海应用技术学院学报：自然科学版 </a> </span> <span> . 2016</span><span>,第4期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_modern-chemical-research_thesis/0201272316525.html">天然高分子催化剂的制备以及在C-C偶联中的应用</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=舒琴1&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 舒琴1</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李紫茹1&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,李紫茹1</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杨海霞1&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,杨海霞1</a> <span> <a href="/journal-cn-39108/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 当代化工研究 </a> </span> <span> . 2019</span><span>,第002期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_modern-chemical-research_thesis/0201275754055.html">天然高分子催化剂的制备以及在C-C偶联中的应用</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=舒琴&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 舒琴</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李紫茹&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,李紫茹</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杨海霞&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,杨海霞</a> <span> <a href="/journal-cn-9156/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 化工中间体 </a> </span> <span> . 2019</span><span>,第002期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-67038_thesis/020223029940.html">环糊精/Pd(Ⅱ)超分子配体催化C-C偶联反应</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=罗开秀&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 罗开秀</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=蒋涵&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,蒋涵</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杨睿&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,杨睿</a> <span> <a href="/conference-cn-67038/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 全国第十九届大环化学暨第十一届超分子化学学术讨论会 </a> <span> <span> . 2018</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/02031379873.html">吡啶烯酮类螺硼酸酯和[2.2]环仿基硼氟分子的构筑及其荧光性质研究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李康&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 李康</a> <span> . 2019</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120113537795.html">具有超高分子量能力和超低共聚单体结合的单齿氨基吡啶第IV族过渡金属烯烃共聚催化剂</a> <b>[P]</b> . <span> 中国专利： CN113597438A </span> <span> . 2021-11-02</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120112682258.html">一种基于分子内或分子间非对称有机分子电催化剂的制备方法及其在锌空电池中的应用</a> <b>[P]</b> . <span> 中国专利： CN112736258A </span> <span> . 2021-04-30</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130455984950.html">PROCESS FOR THE PREPARATION OF 2-(METHOXY-IMINO)-2-ARYL-ACETIC ESTER DERIVATIVES VIA PALLADIUM-CATALYZED CROSS COUPLING REACTION, BORON ACIDES INTERMEDIATES THEREOF AND USE OF THE LATTER</a> <b>[P]</b> . <span> 外国专利：  HUT75179A </span> <span> . 1997-04-28</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：通过钯催化的交叉偶联反应制备2-（甲氧基-亚氨基）-2-芳基-芳族酯衍生物的方法，硼酸介导了它们的合成和陶瓷的使用 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130409415059.html">Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds</a> <b>[P]</b> . <span> 外国专利：  DK1390340T3 </span> <span> . 2017-05-15</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：铜催化的碳杂原子和碳碳键的形成 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130411020449.html">COPPER-CATALYZED FORMATION OF CARBON-HETEROATOM AND CARBON-CARBON BONDS</a> <b>[P]</b> . <span> 外国专利：  EP1390340B1 </span> <span> . 2017-03-01</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：铜-碳杂原子和碳-碳键的铜催化形成 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704028161274','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img src="https://cdn.zhangqiaokeyan.com/img/loginclose.png" alt="关闭" onclick="$('.journalsub-pop-up').hide()"> <p class="pardon">抱歉，该期刊暂不可订阅，敬请期待！</p> <p class="current">目前支持订阅全部北京大学中文核心（2020）期刊目录。</p> <div style="display: flex;margin-top: 69px;justify-content: space-between;"> <div class="no-sub" onclick="$('.journalsub-pop-up').hide()">暂不订阅</div> <div class="other-sub" onclick="continueSub('from=pc-detail')">继续订阅其他期刊</div> </div> </div> </div> <div class="right_btn"> <ul> <li class="gouwuche">  </li> <li class="yijian"> <a href="javascript:void(0);" onclick="link_analysis('/mycenter/auth/complaint.html',this)" title="意见反馈">意见反馈</a> </li> <li class="top"> <a href="javascript:scrollTo(0,0);" title="回到顶部">回到顶部</a> </li> <li class="shouye"> <a href="/" title="首页">回到首页</a> </li> </ul> </div> <div class="xllindexfooter"> <div class="xllindexfootercenter"> <div class="xllindexfooterleft left" > <div class="xllindexfooterleftli"> <ul> <li><a href="/about.html" title="关于掌桥">关于掌桥</a></li> <li><a href="/help/helpmap.html" title="资源导航">资源导航</a></li> <li><a href="/help/helpguide.html" title="新手指南">新手指南</a></li> <li><a href="/help/helpcenter.html" title="常见问题">常见问题</a></li> <li><a href="/sitemap.html" title="网站地图">网站地图</a></li> <li><a href="/help/helpcenter.html?type=9" title="版权声明">版权声明</a></li> </ul> </div> <div class="xllindexfooterleft"> <p class="xllindexfooterlefteamil">客服邮箱：kefu@zhangqiaokeyan.com</p> <div class="xllindexfooterlefttcp"> <div class="xllindexfooterpoliceiimg"></div> <div class="xllindexfooterpoliceispan"> <span>京公网安备：11010802029741号 </span> <span>ICP备案号：<a href="https://beian.miit.gov.cn" rel="nofollow" target="_blank" title="ICP备案号">京ICP备15016152号-6</a></span> <span>六维联合信息科技 (北京) 有限公司©版权所有</span> </div> </div> </div> </div> <div class="xllindexfooterright left"> <ul> <li> <p style="font-weight: bold;">客服微信</p> <div></div> </li> <li> <p style="font-weight: bold;">服务号</p> <div></div> </li> </ul> </div> </div> </div> <span id="0704028161274down" data-source="7," data-out-id="jkBBnMI/tCjC25stdEdIPtK02nMhaYcikopjjJoKglwps4Qzs980jvX+8FbCzKtd," data-f-source-id="7" data-title="Stereoinvertive C–C Bond Formation at the Boron‐Bound Stereogenic Centers through Copper‐Bipyridine‐Catalyzed Intramolecular Coupling of α‐Aminobenzylboronic Esters" data-price="20" data-site-name="" data-transnum="24" style="display:none;"></span> <input type="hidden" value="4" id="sourcetype"> <input type="hidden" value="19011" id="journalid"> <input type="hidden" value="1" id="inyn_provide_service_level"> <input type="hidden" value="https://cdn.zhangqiaokeyan.com" id="imgcdn"> <input type="hidden" value="1" id="isdeatail"> <input type="hidden" value="" id="syyn_indexed_database"> <input type="hidden" value="" id="servicetype"> <input type="hidden" id="pagename" value="Stereoinvertive C–C Bond Formation at the Boron‐Bound Stereogenic Centers through Copper‐Bipyridine‐Catalyzed Intramolecular Coupling of α‐Aminobenzylboronic Esters"/> <input type="hidden" value="thesis_get_original" id="pageIdentification"> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery-1.12.4.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/lwlh_ajax.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zq.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/common.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery.cookie.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/top.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/tip.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/login.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/down.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/search.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/newmail.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/searchtype.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/user/regist.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zxs_solor/detail.js?v=5.7.8"></script> <script type="text/javascript" src="https://www.zhangqiaokeyan.com/statistics/static/pagecollection.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/tj.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/sse.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/pushbaidu.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/history.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/util/cookie.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/weipu/weipu.js?v=5.7.8"></script> </body> <script> $(function(){ var weiPuStatus = getCookie('WeiPuStatus'); if(weiPuStatus){ tipWeiPuStatus(weiPuStatus); delCookie('WeiPuStatus'); } getFacetKeywordVoInId(); var sourcetype = $("#sourcetype").val(); var inyn_provide_service_level = $("#inyn_provide_service_level").val(); if((sourcetype ==1||sourcetype==4)&&inyn_provide_service_level!=4){ getJournal(); } }) </script> </html>