FerriIridium: A Lysosome‐Targeting Iron(III)‐Activated Iridium(III) Prodrug for Chemotherapy in Gastric Cancer Cells

Kuang Shi; Liao Xinxing; Zhang Xianrui; Rees Thomas W.; Guan Ruilin; Xiong Kai; Chen Yu; Ji Liangnian; Chao Hui

摘要

Abstract > Reported is the Fe III ‐activated lysosome‐targeting prodrug FerriIridium for gastric cancer theranostics. It contains a meta ‐imino catechol group that can selectively bond to, and be oxidized by, free Fe III inside the cell. Subsequent oxidative rearrangement releases Fe II and hydrolyses the amine bond under acidic conditions, forming an aminobipyridyl Ir complex and 2‐hydroxybenzoquinone. Thus, Fe II catalyzes the Fenton reaction, transforming hydrogen peroxide into hydroxyl radicals, the benzoquinone compounds interfere with the respiratory chain, and conversion of the prodrug into the Ir complex leads to an increase in phosphorescence and toxicity. These properties, combined with the high Fe III content and acidity of cancer cells, make FerriIridium a selective and efficient theranostic agent (IC <sub>50</sub> =9.22?μ <sc>m</sc> for AGS cells vs. 200?μ <sc>m</sc> for LO2 cells). FerriIridium is the first metal‐based compound that has been developed for chemotherapy using Fe III to enhance both selectivity and potency. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > 报告是FE iii </ sup> - 活化的溶酶体靶向前药 <B> Ferriiridium </ B> 用于胃癌治疗。它包含A. meta </ i> -Imino儿茶醇组可以选择性地粘合，并通过免费FE氧化 iii </ sup> 在细胞内。随后的氧化重排释放释放Fe ii </ sup> 并在酸性条件下水解胺键，形成氨基吡啶基红外络合物和2-羟基苯醌。因此，Fe. ii </ sup> 催化芬顿反应，将过氧化氢转化为羟基自由基，苯醌化合物干扰呼吸链，并将前药转化为红外复合物导致磷光和毒性的增加。这些属性与高FE相结合 iii </ sup> 癌细胞的含量和酸度，使 <B> Ferriiridium </ B> 一种选择性和高效的Theranostic Agent（IC <sub> 50 </ sub> = 9.22？μ <sc> m </ sc> 对于AGS细胞与＆ 200？μ <sc> m </ sc> 对于LO2细胞）。 <B> Ferriiridium </ B> 是第一种用于使用Fe的化疗开发的金属基化合物 iii </ sup> 增强选择性和效力。 </ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-19011/'>《Angewandte Chemie》</a> <b style="margin: 0 2px;">|</b><span>2020年第8期</span><b style="margin: 0 2px;">|</b><span>共7页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kuang Shi&option=202" target="_blank" rel="nofollow">Kuang Shi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liao Xinxing&option=202" target="_blank" rel="nofollow">Liao Xinxing;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Xianrui&option=202" target="_blank" rel="nofollow">Zhang Xianrui;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Rees Thomas W.&option=202" target="_blank" rel="nofollow">Rees Thomas W.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Guan Ruilin&option=202" target="_blank" rel="nofollow">Guan Ruilin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Xiong Kai&option=202" target="_blank" rel="nofollow">Xiong Kai;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chen Yu&option=202" target="_blank" rel="nofollow">Chen Yu;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ji Liangnian&option=202" target="_blank" rel="nofollow">Ji Liangnian;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chao Hui&option=202" target="_blank" rel="nofollow">Chao Hui;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>MOE Key Laboratory of Bioinorganic and Synthetic ChemistrySun Yat-Sen UniversityGuangzhou 510275 P. R. China;</p> <p>MOE Key Laboratory of Bioinorganic and Synthetic ChemistrySun Yat-Sen UniversityGuangzhou 510275 P. R. China;</p> <p>MOE Key Laboratory of Bioinorganic and Synthetic ChemistrySun Yat-Sen UniversityGuangzhou 510275 P. R. China;</p> <p>MOE Key Laboratory of Bioinorganic and Synthetic ChemistrySun Yat-Sen UniversityGuangzhou 510275 P. R. China;</p> <p>MOE Key Laboratory of Bioinorganic and Synthetic ChemistrySun Yat-Sen UniversityGuangzhou 510275 P. R. China;</p> <p>MOE Key Laboratory of Bioinorganic and Synthetic ChemistrySun Yat-Sen UniversityGuangzhou 510275 P. R. China;</p> <p>MOE Key Laboratory of Bioinorganic and Synthetic ChemistrySun Yat-Sen UniversityGuangzhou 510275 P. R. China;</p> <p>MOE Key Laboratory of Bioinorganic and Synthetic ChemistrySun Yat-Sen UniversityGuangzhou 510275 P. R. China;</p> <p>MOE Key Laboratory of Bioinorganic and Synthetic ChemistrySun Yat-Sen UniversityGuangzhou 510275 P. R. China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1188.html" title="应用化学">应用化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=bioinorganic chemistry&option=203" rel="nofollow">bioinorganic chemistry;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=cancer&option=203" rel="nofollow">cancer;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=cytotoxicity&option=203" rel="nofollow">cytotoxicity;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=iridium&option=203" rel="nofollow">iridium;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=medicinal chemistry&option=203" rel="nofollow">medicinal chemistry;</a> </p> <div class="translation"> 机译：生物有机化学;癌症;细胞毒性;铱;药用化学; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704028160660.html">FerriIridium: A Lysosome‐Targeting Iron(III)‐Activated Iridium(III) Prodrug for Chemotherapy in Gastric Cancer Cells</a> <b>[J]</b> . 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