Fluorobis(phenylsulfonyl)methane: A Fluoromethide Equivalent and Palladium-Catalyzed Enantioselective Allylic Monofluoromethylation

摘要

The development of efficient methodology for the synthesis of fluoroorganic compounds has attracted considerable attention particularly in the field of medicinal chemistry.[1] Owing to their unique and significant biological properties, fluorinated drugs have been commonly used in the treatment of a variety of diseases. Fluorination and fluoroalkylation reactions are two straightforward operations for the construction of fluorine-containing molecules, and their asymmetric versions are particularly useful.