Asymmetric Intramolecular Crossed-Benzoin Reactions by N-Heterocyclic Carbene Catalysis

摘要

The discovery of stable carbenes in the last decade of the 20th century has brought about extensive research on the chemistry of N-heterocyclic carbenes. With respect to the biochemistry of the coenzyme thiamine (vitamin B1, a natural thiazolium salt), where the catalytically active species has been proposed to be a carbene, investigations on N-heterocyclic carbenes focussed on the catalysis of organic reactions side by side with their use as ligands for organometallic chemistry.