Relativistic Functional Groups: Aryl Carbon– Gold Bond Formation by Selective Transmetalation of Boronic Acids

摘要

The rational design of triplet-state sensitizers for the photodynamic therapy of cancers[1–3] and other diseases[4] remains an obdurate challenge. A prominent strategy[5–7] is the modification of existing photosensitizers with bromine (Z=35) or iodine (Z=53); the resulting heavy-atom effects potentiate the generation of therapeutic 1Dg O2. The (phosphane) gold(I) fragment is s-isolobal with the proton. Terminal substitution of aromatic organic molecules with gold (Z=79) has clear desirability for developing phototherapy mediators. What is missing are mild means of carbon–gold bondformation in the presence of sensitive functional groups.