Direct Amino Acid Catalyzed Asymmetric Synthesis of Polyketide Sugars

摘要

The directed asymmetric assembly of simple achiral building blocks into stereochemically complex molecules like carbohydrates and polyketides has long been accomplished by enzymes in nature.The growing interest in glycobiology and the search for novel antibiotics has led to increased activity in developing reaction designs and methods for the synthesis of sugars and polyketides.