A Family of Hierarchically Self-Assembling Linear-Dendritic Hybrid Polymers for Highly Efficient Targeted Gene Delivery

摘要

To fully realize the potential for new medical advances in the postgenomic era,safe and efficient delivery systems for nucleotide-based drugs must be developed.Ideally,such systems will be nontoxic,nonimmunogenic,and made from versatile building blocks that allow optimal delivery to a range of cells or tissues of interest.Herein,for the first time,we present the design,synthesis,and evaluation of a unique family of hierarchically structured linear-dendritic hybrid polymers that self-assemble with DNA to form stable nano-particles with a series of concentric,functional "shells" that display independently tuneable properties necessary for effective targeted delivery.