New Iodination Reactions of Saturated Hydrocarbons

摘要

Selective processes that afford functionalized derivatives from the reaction of nonactivated CH bonds are of current interest.[1] Bromination and chlorination reactions are valuable tools for this purpose with saturated hydrocarbons.[2] However, the related iodination is not so well developed.[3] Herein, we report on new iodination reactions of alkanes under mild thermal conditions. The process relies on the use of the combination of hypervalent iodine, I2, and trimethylsilyl azide (TMSN3). Furthermore, a related and efficient iodination in water, using H2O2 as a convenient source for the oxidant, has also been established.