Sequence Symmetry as a Tool for Designing DNA Nanostructures

摘要

DNA sequence symmetry brings at least three advantages to any given DNA structure:1)minimization of the required sequence space and simplification of sequence design;reduction of the number of different DNA strands;and cancellation of some unpredictable distortions in DNA nanostructures,thus allowing DNA two-dimensional(2D) arrays to grow to large sizes.Herein,DNA sequence symmetry is introduced into the design of DNA nanostruc tures,to give DNA 2D arrays that reach a width of 1 mm.