Metal-Free,Organocatalytic Asymmetric Transfer Hydrogenation of alpha,beta-Unsaturated Aldehydes

摘要

Asymmetric catalytic hydrogenations are used in the large-scale industrial production of pharmaceuticals and fine chemicals and also by all living organisms.While chemical hydrogenations require metal catalysts or the use of stoichio-metric amounts of metal hydrides,living organisms typically rely on organic cofactors such as nicotinamide adenine dinucleotide (NADH) in combination with metalloen-zymes.