Catalytic Desymmetrizing Intramolecular Heck Reaction:Evidence for an Unusual Hydroxy-Directed Migratory Insertion

摘要

As reflected by a remarkable number of beautiful applications to the synthesis of structurally intriguing natural products,the asymmetric intramolecular Heck reaction has evolved as a prominent carbon-carbon bond-forming process.The invention of asymmetric variants of Heck cyclizations has been approached by two distinct strategies:by indirect and by direct formation of stereogenic carbon centers.