Enhancing the Enantioselectivity of Novel Homogeneous Organometallic Hydrogenation Catalysts

摘要

The exigent need to develop new asymmetric hydrogenation catalysts is universally acknowledged, and many new feasible strategies for the design and synthesis of such catalysts continue to be proposed. Herein, in addition to describing a new set of efficient, diamino-type ligands for a central rhodium or palladium ion that leads to good enantioselective (ee) performance, homogeneously, we also show that significant improvement in the stereoselectivity of the organometallic catalyst may be achieved by heterogenizing it at the inner walls of amesoporous silica so that advantage is taken of the spatial restrictions imposed by the concave surface at which we have located the active center.