Biomimetie Extradiol Cleavage of Catechols: Insights into the Enzyme Mechanism

摘要

The catechoi dioxygenases are a class of nonheme iron enzymes that catalyze the oxidath e cleavage of catechols as part of nature's biodegradation pathway for aromatic molecules. These enzymes can be divided into two subclasses: intradiol-cleaving enzymes, which break the catechoi C1-C2 bond, and extradiol-cleaving enzymes, which break the C2-C3 bond (Scheme l).