Amphiphilic/Bipolar Metallocorroles That Catalyze the Decomposition of Reactive Oxygen and Nitrogen Species,Rescue Lipoproteins from Oxidative Damage,and Attenuate Atherosclerosis in Mice

摘要

Accumulating evidence points towards the involvement of reactive oxygen and nitrogen species(ROS and RNS,respectively)in a very wide variety of diseases.The relationship between atherosclerosis and oxidativeitrosa-tive stress-the imbalance between the desired production of ROS/RNS and the capability of biological systems to detoxify excess amounts thereof-is often analyzed in terms of damage to the cholesterol-transporting high-and low-density lipoproteins(HDL and LDL,respectively).