Asymmetric Total Synthesis and X-Ray Crystal Structure of the Cytotoxic Marine Diterpene(+)-Vigulariol

摘要

(+)-Vigulariol(1)is a cytotoxic,tetracyclic diterpene which has been isolated from the sea pen Vigularia juncea.It belongs to the impressively large class of the cladiellin(eunicellin)diterpenes,of which many bear interesting biological activities.