Catalytic Asymmetric Michael Reactions of Acetaldehyde

摘要

Enamine catalysis recently emerged as a powerful method for the direct use of ketones and aldehydes as nucleophiles in asymmetric catalysis.The scope of this chemistry is growing and a large number of electrophiles,including carbonyl compounds,imines,Michael acceptors,and many other useful reagents,have been employed.Even reactions that had been considered impossible,such as aldehyde cross aldolizations and alpha-alkylations,became a reality by using this approach.